Molecular structure of Brivudine, CAS Number: 69304-47-8
Brivudine (CAS 69304-47-8)
See product citations (4)
Alternate Names:
BVdU
Application:
Brivudine is an antiviral compound
CAS Number:
69304-47-8
Molecular Weight:
333.14
Molecular Formula:
C11H13BrN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Brivudine, an acyclic nucleoside analog, exhibits potent antiviral properties through the inhibition of viral replication. Its chemical structure is derived from thymidine. To expand understanding of brivudine′s effectiveness and safety, researchers have conducted in vitro studies.
Brivudine (CAS 69304-47-8) References
- Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. | Rabasseda, X. 2003. Drugs Today (Barc). 39: 359-71. PMID: 12861349
- [Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. | Vij, O., et al. 2003. Klin Monbl Augenheilkd. 220: 710-5. PMID: 14577039
- Linear Darier disease with herpes zoster superinfection treated successfully by brivudine. | Abraham, S., et al. 2006. Br J Dermatol. 154: 365-7. PMID: 16433812
- Fatal drug-drug interaction of brivudine and capecitabine. | Rätz Bravo, AE., et al. 2009. Acta Oncol. 48: 631-3. PMID: 19165642
- Epstein-Barr virus encephalitis after kidney transplantation and successful treatment with brivudine. | Lahmer, T., et al. 2010. Transpl Int. 23: e24-5. PMID: 20070626
- Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet. | Bleymehl, K., et al. 2011. Med Microbiol Immunol. 200: 193-202. PMID: 21373931
- RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients. | Heinrich, JC., et al. 2011. J Cancer Res Clin Oncol. 137: 1349-61. PMID: 21833720
- Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine. | Zhang, NQ., et al. 2012. Asian Pac J Cancer Prev. 13: 2121-7. PMID: 22901180
- L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation. | Gao, LJ., et al. 2016. Bioorg Med Chem Lett. 26: 2142-6. PMID: 27032331
- Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus. | Ugurlu, S., et al. 2014. Neuroophthalmology. 38: 260-263. PMID: 27928310
- Separating host and microbiome contributions to drug pharmacokinetics and toxicity. | Zimmermann, M., et al. 2019. Science. 363: PMID: 30733391
- Neural Progenitor Cells Expressing Herpes Simplex Virus-Thymidine Kinase for Ablation Have Differential Chemosensitivity to Brivudine and Ganciclovir. | Lou, Z., et al. 2021. Front Cell Neurosci. 15: 638021. PMID: 34938162
- Intestinal Apc-inactivation induces HSP25 dependency. | van Neerven, SM., et al. 2022. EMBO Mol Med. 14: e16194. PMID: 36321561
Inhibitor of:
HERPUD2, HHV-6, HSV-1 gB, HSV-1 Glycoprotein D, HSV-1 ICP0, HSV-1 ICP4, HSV-1 Thymidine Kinase, HSV-1 UL42, HSV-2 gD, HSV-2 gE Envelope Protein, HSV-2 gG, HSV-2 gG Envelope Protein, HSV-2 ICP10, KSHV ORF 62, Trp E, Varicella Zoster Virus gpI, Varicella Zoster Virus gpIII, Varicella Zoster Virus gpIV, Varicella Zoster Virus IE62, Varicella Zoster Virus IV, Varicella-Zoster Virus (VZV), VZV gE, VZV IE62, and VZV thymidine kinase.Activator of:
HSV-2 gB, HSV-2 ICP8 Major DNA binding protein, and HSV-2 VP22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Brivudine, 10 mg | sc-205607 | 10 mg | $224.00 | |||
Brivudine, 25 mg | sc-205607A | 25 mg | $469.00 | |||
Brivudine, 100 mg | sc-205607B | 100 mg | $1020.00 | |||
Brivudine, 1 g | sc-205607C | 1 g | $2142.00 |