Vidarabine CAS: 5536-17-4
MF: C10H13N5O4
MW: 267.24
A neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes.

Vidarabine (CAS 5536-17-4)

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同义词: Arabinosyladenine; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
应用; A neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes
CAS号码: 5536-17-4
纯度: ≥99%
分子量: 267.24
分子式: C10H13N5O4
* 参考分析证明 大量特定数据 (包括水 含量).
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Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase.


参考文献

Honma Y, Nitsu N. Leuk Lymphoma. 399:57-66 (2000). Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247.

物理状态 :
Solid
溶解度 :
Soluble in DMF (10 mg/ml), 0.5 M HCl (50 mg/ml), DMSO (53 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and water (3 mg/ml at 25° C).
保存 :
Store at -20° C
熔点 :
260° C
沸点 :
676.27° C at 760 mmHg (Predicted)
密度 :
~2.1 g/cm3 (Predicted)
折射率 :
n20D 1.91 (Predicted)
光学活性 :
α20/D -60.5°±4.5° in DMF
IC50 :
PRK cell line: IC50 = 0.4 ug.mL-1; Moloney murine leukemia virus: IC50 = 1 ug.mL-1; herpesvirus 1: IC50 = 5.6 ug.mL-1 (human); CCRF-HSB-2: IC50 = 12.9 ug.mL-1 (human); HL-60: IC50 = 20.9 ug.mL-1 (human)
Ki 数据 :
Adenosylhomocysteinase : Ki= 30 µM (rat)
pK值 :
pKa: 13.11 (Predicted), pKb: 3.82 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
AU6200000
PubChem CID :
21704
默克索引 :
14: 9976
MDL 号码 :
MFCD00065471
EC号码 :
226-893-9
Beilstein 注册 :
624881
SMILES :

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引用1 - 11

PMID: # 26416623  Lehouritis, P. et al. 2015. Sci Rep. 5: 14554.

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