Dibutyryl-cGMP (CAS 51116-00-8)
See product citations (11)
QUICK LINKS
Dibutyryl-cGMP, a membrane permeable cGMP analog, used in various experiments to model cGMP interactions and effects on different biological molecules. This compound has been reported to play a role of an intracellular messenger in primary sensory neurons of the autonomic nervous system. Studies suggest that Dibutyryl-cGMP modulates a dihydropyridine-sensitive Ca2+ entry mechanism in rat pituitary cells. In vitro experiments on pancreatic acinar cells and guinea pig gallbladder cells suggest that this product competitively inhibits the contractile effect of cholecystokinin octapeptide, and contraction induced by sulfated gastrin-17. Furthermore, Dibutyryl-cGMP demonstrates the ability to shorten and reduce repolarization, overshoot of action potentials, and slightly hyperpolarize the cells in the atrial working muscle.
Dibutyryl-cGMP (CAS 51116-00-8) References
- Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore. | Takuma, K., et al. 2001. J Biol Chem. 276: 48093-9. PMID: 11677240
- Effects of nitric oxide and cGMP on inhibin A and inhibin subunit mRNA levels from cultured rat granulosa cells. | Chen, YH., et al. 2003. Fertil Steril. 79 Suppl 1: 687-93. PMID: 12620478
- Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP. | Alves, DP., et al. 2004. Eur J Pharmacol. 489: 59-65. PMID: 15063156
- cGMP decreases surface NKCC2 levels in the thick ascending limb: role of phosphodiesterase 2 (PDE2). | Ares, GR., et al. 2008. Am J Physiol Renal Physiol. 295: F877-87. PMID: 18684888
- Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo. | Koriyama, Y., et al. 2009. J Neurochem. 110: 890-901. PMID: 19457064
- The influence of dibutyryl cGMP on the rabbit auricle. | Tuganowski, W., et al. 1978. Pol J Pharmacol Pharm. 30: 73-5. PMID: 205846
- Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton. | Kitamura, E., et al. 2011. PLoS One. 6: e20707. PMID: 21738583
- Opposite regulatory effects of cAMP and cGMP on sugar uptake in rat thymocytes. | Segal, J. 1987. Am J Physiol. 252: E588-94. PMID: 2437804
- In vivo evidence that cGMP is the second messenger for atrial natriuretic factor. | Huang, CL., et al. 1986. Proc Natl Acad Sci U S A. 83: 8015-8. PMID: 3020563
- Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs. | Monzon, CM. and Garvin, JL. 2019. Am J Physiol Renal Physiol. 317: F411-F418. PMID: 31166708
- Dibutyryl cGMP: inhibitor of the effect of cholecystokinin and gastrin on the guinea pig gallbladder in vitro. | Poitras, P., et al. 1980. Biochem Biophys Res Commun. 96: 476-82. PMID: 6254515
- Gastric bicarbonate secretion: an update. | Kauffman, GL. 1980. Brain Res Bull. 5 Suppl 1: 15-8. PMID: 6992944
- cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes. | Chik, CL., et al. 1995. J Neurosci. 15: 3104-9. PMID: 7536827
- Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells. | Willmott, NJ., et al. 1996. FEBS Lett. 386: 39-42. PMID: 8635599
- Dibutyryl cGMP raises cytosolic concentrations of Ca2+ in cultured nodose ganglion neurons of the rabbit. | Sato, M. and Kawatani, M. 1998. Brain Res. 813: 203-6. PMID: 9824699
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dibutyryl-cGMP, 10 mg | sc-200321 | 10 mg | $153.00 | |||
Dibutyryl-cGMP, 50 mg | sc-200321A | 50 mg | $398.00 |