The chemical class known as Vmn2r86 Inhibitors encompasses a range of compounds that indirectly target the signaling mechanisms associated with the Vmn2r86 receptor. This receptor, belonging to the vomeronasal type 2 receptor family, plays a crucial role in the detection of pheromonal signals, with its activity being mediated through complex intracellular pathways characteristic of G protein-coupled receptors. Given the absence of direct inhibitors, the strategy employed focuses on modulating the broader signaling landscape within which Vmn2r86 operates. By targeting key regulatory molecules and pathways such as cAMP production, calcium signaling, and various kinase activities, these inhibitors can alter the cellular context and modulate the receptor's function. This approach not only provides insights into the functional modulation of Vmn2r86 but also highlights the intricate web of cellular signaling pathways that govern sensory perception and response mechanisms at the molecular level.
This exploration into the potential modulation of Vmn2r86 through indirect inhibitors exemplifies the complexity of signaling networks and the nuanced strategies required to influence receptor activity. The selected compounds, by acting on various signaling intermediates, offer a toolkit for investigating the physiological roles of Vmn2r86 and the mechanisms by which it contributes to pheromone detection and signaling. Through such investigations, the inhibitors facilitate a deeper understanding of the molecular underpinnings of sensory signaling and the interplay between different signaling modules. This approach underscores the potential of targeted chemical intervention to unravel the signaling dynamics of vomeronasal receptors, providing a foundation for further research into the molecular basis of sensory processes and their regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, potentially disrupting Vmn2r86-mediated signaling by overstimulation of the pathway. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Chelates intracellular Ca2+, potentially inhibiting Vmn2r86-related signal transduction dependent on calcium. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A PKC inhibitor, could disrupt downstream signaling pathways of Vmn2r86 by inhibiting kinase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor, could prevent AKT pathway activation, affecting Vmn2r86-mediated responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor, potentially blocking ERK pathway activation downstream of Vmn2r86. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor, might inhibit Vmn2r86-related stress response signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, could affect apoptosis pathways linked to Vmn2r86 signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor, reinforcing the blockade of AKT pathway activation related to Vmn2r86. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Inhibits CaMKII, affecting calcium-dependent signaling pathways of Vmn2r86. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src kinase inhibitor, potentially disrupting kinase-dependent signaling cascades of Vmn2r86. | ||||||