Vmn1r118 Activators
Vomeronasal 1 receptor 118 activators represent a group of chemical compounds that enhance the functional activity of this receptor through various signaling mechanisms. Forskolin, for instance, acts by directly stimulating adenylate cyclase, which catalyzes the conversion of ATP to cAMP, an intracellular messenger that plays a pivotal role in the signaling pathways of the vomeronasal 1 receptor 118. The increased cAMP levels, in turn, activate PKA, which phosphorylates specific target proteins, thereby enhancing the receptor's signaling efficiency. Similarly, 8-Bromo-cAMP, a cAMP analog, bypasses cellular regulatory mechanisms to elevate cAMP levels, ensuring the activation of cAMP-dependent pathways and the subsequent activation of PKA, which then enhances the signaling of vomeronasal 1 receptor 118.
Additionally, compounds that modulate intracellular calcium levels, such as ionomycin and A23187, can also indirectly enhance the activity of vomeronasal 1 receptor 118. Elevated intracellular calcium triggers the activation of calcium-dependent kinases and phosphatases that are integral to the receptor's signaling pathway. PMA, as a PKC activator, and genistein, through its inhibition of tyrosine kinases, both contribute to the regulation of phosphorylation status within the receptor's signaling network, thereby enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates the enzyme adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP can enhance the function of vomeronasal 1 receptor 118 by promoting the phosphorylation of proteins involved in its signaling pathway. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that resists degradation by phosphodiesterases. This compound can increase intracellular cAMP, thereby enhancing the activity of protein kinase A (PKA), which can phosphorylate various proteins that may be part of the vomeronasal 1 receptor 118 signaling cascade. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Since calcium is a secondary messenger in the signaling of vomeronasal 1 receptor 118, ionomycin can indirectly enhance the receptor's activity by modulating calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC can phosphorylate target proteins within the signaling pathways of vomeronasal 1 receptor 118, which can enhance the receptor's functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can lead to the activation of adenylate cyclase and consequently increase intracellular cAMP levels. This elevation can indirectly enhance the functional activity of vomeronasal 1 receptor 118 through cAMP-dependent pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, thus potentially enhancing the signaling of vomeronasal 1 receptor 118 through calcium-mediated pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP in cells. This raises the levels of these cyclic nucleotides, thereby indirectly enhancing the signaling pathways of vomeronasal 1 receptor 118 that are cAMP or cGMP dependent. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that can modulate intracellular calcium levels. By controlling calcium dynamics within the cell, BAPTA-AM can indirectly influence calcium-dependent signaling processes associated with vomeronasal 1 receptor 118. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases. This activation can lead to the phosphorylation of proteins that are part of the signaling pathways of vomeronasal 1 receptor 118, potentially enhancing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can interfere with phosphorylation events downstream of G protein-coupled receptors like vomeronasal 1 receptor 118. By modulating tyrosine kinase activity, genistein can indirectly enhance the receptor's signaling. | ||||||