Vmn1r113 Inhibitors
Vmn1r113, a member of the vomeronasal type 1 receptor family, plays a pivotal role in the intricate olfactory system, specifically within the vomeronasal organ (VNO). This receptor is integral to the detection and transduction of pheromonal signals, contributing to the social and reproductive behaviors of organisms. Vmn1r113 is part of a large family of G-protein-coupled receptors (GPCRs) characterized by a seven-transmembrane domain structure. As a GPCR, Vmn1r113 shares similarities with other neurotransmitter and hormone receptors, particularly in its involvement in G protein-mediated transduction of signals initiated by odorant molecules binding to the receptor. The primary function of Vmn1r113 involves interacting with specific odorant molecules present in the environment. This interaction triggers a cascade of events, including the activation of G proteins and subsequent signaling pathways, ultimately leading to the initiation of a neuronal response. The olfactory receptor proteins, like Vmn1r113, are expressed in the VNO and are crucial for recognizing and transducing odorant signals. This recognition is highly specific, with each receptor being responsive to particular types of odorants. The vast olfactory receptor gene family, including Vmn1r113, contributes to the diversity and complexity of the olfactory system, allowing organisms to discern a wide array of odors in their environment.
The general mechanisms of Vmn1r113 activation involve intricate signal transduction processes initiated upon binding of specific odorant molecules. When an odorant molecule binds to the extracellular domain of Vmn1r113, it induces a conformational change in the receptor, leading to the activation of associated G proteins. These G proteins then initiate intracellular signaling cascades, involving various second messengers and protein kinases, which eventually culminate in the generation of action potentials in the sensory neurons connected to Vmn1r113. The activation of Vmn1r113 is finely tuned, ensuring specificity in response to distinct odorants. The subsequent neural signals are transmitted to higher brain centers, enabling the perception and processing of olfactory stimuli. Understanding the activation mechanisms of Vmn1r113 provides insights into the fundamental processes governing chemosensory perception and the intricate interplay between receptors, odorants, and neural responses within the vomeronasal system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atropine | 51-55-8 | sc-252392 | 5 g | $204.00 | 2 | |
Blocks muscarinic acetylcholine receptors, disrupting intracellular signaling pathways crucial for olfactory receptor function. This inhibition leads to impaired responsiveness of Vmn1r113 to specific odorants, affecting the vomeronasal system's sensitivity. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Inhibits purinergic receptor signaling, indirectly influencing Vmn1r113 activation. Disruption of purinergic signaling cascades hinders proper olfactory receptor function, diminishing the neuronal responses to specific odorants detected by Vmn1r113. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that alters chromatin structure around the Vmn1r113 gene locus. By promoting a more closed chromatin state, it impedes transcriptional processes, resulting in reduced expression of Vmn1r113 and inhibition of its olfactory receptor function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that targets the JNK signaling pathway associated with olfactory receptor gene modulation. Inhibition of JNK disrupts the regulatory network controlling Vmn1r113, hindering its proper functioning and diminishing the sensitivity of the vomeronasal system to specific odorants. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
An inhibitor of the PI3K/Akt pathway, crucial for intracellular signal transduction. By disrupting this pathway, LY294002 indirectly inhibits Vmn1r113 function, as the PI3K/Akt signaling axis plays a role in the regulation of olfactory receptor responsiveness and downstream neural activation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
A Wnt pathway antagonist, indirectly affecting Vmn1r113. Inhibition of Wnt signaling alters the cellular context within the vomeronasal organ, influencing the responsiveness of Vmn1r113 to odorant stimuli. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Targets the NF-κB pathway, a regulator of gene expression in response to environmental cues. Inhibition of NF-κB disrupts the normal transcriptional control of Vmn1r113, leading to decreased receptor expression and impaired functionality in the detection of specific odorants. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An MEK1/2 inhibitor affecting the MAPK pathway, which modulates olfactory receptor gene expression. Inhibition of this pathway by U0126 disrupts the regulatory network controlling Vmn1r113, hindering its proper functioning and diminishing the sensitivity of the vomeronasal system to specific odorants. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
A CaMKII inhibitor that disrupts calcium-dependent signaling pathways. Inhibition of CaMKII negatively impacts Vmn1r113 activation, as calcium signaling is crucial for proper olfactory receptor function. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
A GSK-3β inhibitor affecting the Wnt pathway. Inhibition of GSK-3β indirectly influences Vmn1r113, as it disrupts Wnt signaling, altering the cellular context within the vomeronasal organ and impacting the responsiveness of Vmn1r113 to odorant stimuli. | ||||||