VLDLR Inhibitors
VLDLR (Very-Low-Density Lipoprotein Receptor) Inhibitors represent a class of chemical compounds designed to target a specific receptor in the human body known as the VLDLR receptor. This receptor plays a crucial role in lipid metabolism and the regulation of cholesterol levels. VLDLR belongs to the LDL receptor family and is primarily found in tissues such as the liver, heart, and adipose tissue. The main function of VLDLR is to mediate the uptake of triglyceride-rich lipoproteins, particularly very-low-density lipoproteins (VLDLs), into cells. By inhibiting this receptor, VLDLR inhibitors have the ability to modulate lipid homeostasis and impact lipid-related pathways.
Chemically, VLDLR inhibitors can take various forms, including small organic molecules, peptides, or antibodies, which are designed to interact with VLDLR and disrupt its normal functioning. These inhibitors typically work by binding to the VLDLR receptor, preventing its recognition and internalization of VLDL particles. By interfering with this process, VLDLR inhibitors may influence the balance of lipids in circulation, reducing the uptake of cholesterol and triglycerides by cells and thereby affecting overall lipid metabolism. While the exact mechanisms and structures of VLDLR inhibitors may vary, their common goal is to perturb VLDLR activity and thereby provide avenues for research and development in lipid-related disorders and conditions where lipid modulation is of interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin belongs to the statin class of chemicals, known to modulate cholesterol synthesis, potentially influencing VLDLR expression indirectly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound, has been shown to exhibit anti-inflammatory properties and may modulate gene expression, possibly affecting VLDLR levels. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a crucial role in cell growth and differentiation, potentially influencing the expression of VLDLR. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major catechin in green tea, has antioxidative properties and has been shown to modulate the expression of various genes, including VLDLR. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, which has been shown to influence gene expression and might affect VLDLR levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes, has been shown to modulate the expression of various genes, potentially including VLDLR. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride is a biguanide used in the management of diabetes, and it may influence VLDLR expression through its effects on metabolic pathways. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $63.00 $213.00 | 19 | |
Pioglitazone hydrochloride, a thiazolidinedione, acts on PPAR-gamma and has the potential to modulate the expression of various genes, including VLDLR. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate belongs to the fibrate class of chemicals, known to modulate lipid metabolism, potentially affecting the expression of VLDLR. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin has antioxidant properties and has been shown to modulate gene expression, possibly influencing VLDLR levels. | ||||||