Molecular structure of Pioglitazone hydrochloride, CAS Number: 112529-15-4
Pioglitazone hydrochloride (CAS 112529-15-4)
See product citations (19)
Alternate Names:
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride
Application:
Pioglitazone hydrochloride is a specific PPAR-γ ligand
CAS Number:
112529-15-4
Purity:
≥98%
Molecular Weight:
392.91
Molecular Formula:
C19H20N2O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pioglitazone Hydrochloride is the hydrochloride salt preparation of Pioglitazone, a specific ligand of PPAR-gamma (peroxisome proliferator-activated receptor-gamma). Pioglitazone is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent L-NAME-induced coronary inflammation and arteriosclerosis and to suppress increased TNF-alpha mRNA produced by aspirin-induced gastric mucosal injury. Pioglitazone Hydrochloride is an activator of PPAR gamma.
Pioglitazone hydrochloride (CAS 112529-15-4) References
- Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats. | Naito, Y., et al. 2001. Aliment Pharmacol Ther. 15: 865-73. PMID: 11380325
- Determination of pioglitazone hydrochloride in bulk and pharmaceutical formulations by HPLC and MEKC methods. | Radhakrishna, T., et al. 2002. J Pharm Biomed Anal. 29: 593-607. PMID: 12093488
- Antiinflammatory and antiarteriosclerotic effects of pioglitazone. | Ishibashi, M., et al. 2002. Hypertension. 40: 687-93. PMID: 12411463
- Reversed-phase HPLC methods for purity test and assay of pioglitazone hydrochloride in tablets. | Jedlicka, A., et al. 2004. Pharmazie. 59: 178-82. PMID: 15074587
- Thiazolidinediones: a new class of drugs for the therapy of ischemia-reperfusion injury. | Naito, Y. and Yoshikawa, T. 2004. Drugs Today (Barc). 40: 423-30. PMID: 15319797
- Estimation of pioglitazone hydrochloride and metformin hydrochloride in tablets by derivative spectrophotometry and liquid chromatographic methods. | Shankar, MB., et al. 2005. J AOAC Int. 88: 1167-72. PMID: 16152937
- Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation. | Jain, D., et al. 2008. J Chromatogr Sci. 46: 501-4. PMID: 18647470
- Simultaneous Estimation of Metformin Hydrochloride and Pioglitazone Hydrochloride by RPHPLC Method from Combined Tablet Dosage Form. | Sahoo, PK., et al. 2008. Indian J Pharm Sci. 70: 383-6. PMID: 20046754
- Simultaneous determination of metformin hydrochloride and pioglitazone hydrochloride in binary mixture and in their ternary mixture with pioglitazone acid degradate using spectrophotometric and chemometric methods. | Hegazy, MA., et al. 2009. Drug Test Anal. 1: 339-49. PMID: 20355212
- Liquid chromatographic methods for the determination of vildagliptin in the presence of its synthetic intermediate and the simultaneous determination of pioglitazone hydrochloride and metformin hydrochloride. | El-Bagary, RI., et al. 2011. Int J Biomed Sci. 7: 201-8. PMID: 23675237
- Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride. | Chowdary, YA., et al. 2014. J Pharm (Cairo). 2014: 848243. PMID: 26556204
- Effects of pioglitazone hydrochloride and vitamin E on meat quality, antioxidant status and fatty acid profiles in finishing pigs. | Jin, CL., et al. 2018. Meat Sci. 145: 340-346. PMID: 30015164
- Metal-organic framework modified by silver nanoparticles for SERS-based determination of sildenafil and pioglitazone hydrochloride. | Ding, Y., et al. 2021. Mikrochim Acta. 188: 351. PMID: 34554332
- Spectrophotometric methods for determination of glimepiride and pioglitazone hydrochloride mixture and application in their pharmaceutical formulation. | Ghoniem, NS., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 270: 120745. PMID: 34972054
- Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet. | Teaima, M., et al. 2022. Pharmaceutics. 14: PMID: 35214157
Inhibitor of:
Adipogenin, Peroxin 11β, Sclerostin, SUR-1, TGR5, TUG, and VLDLR.Activator of:
9130213B05Rik, ADPN, AI480653, ATP-binding cassette sub-family A (ABCA), BTNL8, C17orf49_0610010K14Rik, C1orf163, caveolin-3, CEACAM7, CIDE-B, COX7a1, CUL-4B, ERR beta, Gemin7, GK3P, Glut4, HMGI-C, IRS-3, Mettl7a2-Higd1c, mitoNEET (CISD1), Myosin XVI, NDUFS3, Ob, PA28β, PC-TP, PPAR gamma, PPRC1, resistin-like α, SCD4, and TREM-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pioglitazone hydrochloride, 100 mg | sc-204848 | 100 mg | $62.00 | |||
Pioglitazone hydrochloride, 500 mg | sc-204848A | 500 mg | $209.00 |