Simvastatin CAS: 79902-63-9
MF: C25H38O5
MW: 418.57
An HMGCR inhibitor and anti-proliferative agent.

Simvastatin (CAS 79902-63-9)

Simvastatin | CAS 79902-63-9 is rated 5.0 out of 5 by 1.
  • y_2020, m_4, d_5, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200829, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 9ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Zocor
Application: An HMGCR inhibitor and anti-proliferative agent
CAS Number: 79902-63-9
Purity: ≥98%
Molecular Weight: 418.57
Molecular Formula: C25H38O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 µM).


References

1. Nègre-Aminou, P., et al. 1997. Biochim. Biophys. Acta. 1345: 259-268. PMID: 9150246
2. Wójcik, C., et al. 2000. Int. J. Biochem. Cell Biol. 32: 957-965. PMID: 11084375
3. Danesh, F.R., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 8301-8305. PMID: 12048257
4. Blanco-Colio, L.M., et al. 2003. Kidney Int. 63: 12-23. PMID: 12472764
5. Chopra, V., et al. 2007. Cardiovasc Drugs Ther. 21: 161-169. PMID: 17468937
6. Wang, H., et al. 2007. Exp. Neurol. 206: 59-69. PMID: 17521631

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol.
Storage :
Store at -20° C
Boiling Point :
~564.9° C at 760 mmHg (Predicted)
Density :
1.11 g/cm3
Refractive Index :
n20D 1.53
IC50 :
HES: IC50 = 6.5 nM; HMG-CoA reductase: IC50 = 3 nM
pK Values :
pKa: 13.49
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
EK7798000
PubChem CID :
54454
Merck Index :
14: 8539
MDL Number :
MFCD00072007

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Simvastatin  Product Citations

See how others have used Simvastatin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 31540279  2019. Cancers (Basel). 11:

PMID: # 20554533  Strauss, K et al. 2010. J. Biol. Chem. 285: 26279-26288.

PMID: # 16613856  Jeon, E.J. et al. 2006. J. Biol. Chem. 281: 16502-16511.

Patino, W et al. 2005. Proc. Natl. Acad. Sci. USA. 102: 3423-3428.

PMID: # 12504826  Hernández-Presa, MA. et al. 2003. Cardiovasc. Res. 57: 168-177.

PMID: # 12406854  Nishimura, T. et al. 2002. Am. J. Respir. Crit. Care Med. 166: 1403-1408.

PMID: # 11815421  Wilson, SH. et al. 2002. Circulation. 105: 415-418.

1999. Science. 286: 1946-1949.

Yokoyama, K et al. 1998. J. Biol. Chem. 273: 26497 - 26505.

PMID: # 31612028  Oncol Lett. 18: 5173-5184.

Citations 1 to 10 of 10 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 20ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Strauss Strauss, et. al. (PubMed ID 20554533) treated cells with simvastatin and L-mevalonate post exposure to LPS (24hr) for 16 hours. They found that caused a large reduction of exosome-associated flotillin-2 release. -SCBT Publication Review
Date published: 2015-06-18
  • y_2020, m_4, d_5, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200829, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 17ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.