VILL Activators
VILL Activators are a niche category of chemical compounds that target and modulate the activity of the villin-like protein (VILL), which is part of the gelsolin superfamily of actin-modulating proteins. VILL plays a crucial role in actin filament assembly and disassembly, processes that are fundamental to cell motility, shape, and division. The unique aspect of VILL activators lies in their ability to enhance the natural activity of the VILL protein, thereby influencing actin dynamics within cells. These activators are developed through complex chemical synthesis, designed to interact specifically with the VILL protein, altering its conformation in a way that promotes its activity towards actin. The design and development of VILL Activators require an intricate understanding of the protein's structure, its actin-binding sites, and the regulatory mechanisms that control its activity. These compounds are characterized by their high specificity to VILL and their ability to modulate its function without interfering with other actin-binding proteins.
The exploration of VILL Activators involves a multidisciplinary research approach, incorporating techniques from biochemistry, molecular biology, and cell biology. Scientists use advanced imaging techniques, such as fluorescence microscopy and live-cell imaging, to observe the effects of these activators on actin dynamics in real time. Biochemical assays, including actin polymerization and depolymerization assays, are employed to quantify the effects of VILL Activators on the activity of VILL and its modulation of actin filament assembly and disassembly. Additionally, computational modeling and simulation studies are conducted to predict the interaction between VILL and its activators, aiding in the refinement of compound design for enhanced efficacy and specificity. Through these comprehensive research efforts, the study of VILL Activators aims to deepen our understanding of the regulation of actin cytoskeleton dynamics, shedding light on the intricate control mechanisms that govern cell morphology and movement.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which can lead to changes in cytoskeletal organization and potentially influence VILL gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression during cell differentiation, which could hypothetically alter VILL expression in differentiating cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that may modulate gene expression by activating protein kinase A, potentially impacting VILL expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can inhibit GSK-3β, leading to changes in cytoskeletal proteins and potentially influencing VILL expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methylation inhibitor that can alter gene expression patterns, possibly affecting VILL gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylases, Trichostatin A can change chromatin structure and gene expression, potentially impacting VILL expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor that can induce changes in gene expression, potentially affecting VILL expression. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
A solvent that can induce differentiation in certain cell types, potentially influencing VILL expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Another histone deacetylase inhibitor that could affect gene expression and potentially alter VILL expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, potentially affecting genes involved in cytoskeletal dynamics like VILL. | ||||||