VCP Activators
VCP (Valosin-containing protein) activators represent a distinctive chemical class within the realm of small molecules that interact with specific cellular proteins. VCP, also known as p97 or CDC48, is an essential enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) superfamily. This enzyme plays a pivotal role in various cellular processes, particularly in protein homeostasis and quality control mechanisms. VCP acts as a hexameric ATPase, utilizing the energy from ATP hydrolysis to unfold and extract proteins from multi-subunit complexes or cellular membranes. VCP activators are a class of compounds designed to modulate the activity of this enzyme, thereby influencing its role in diverse cellular functions.
The chemical structures of VCP activators are diverse, but they share a common objective: to enhance VCP's ATPase activity and promote its function as a molecular machine involved in protein degradation, membrane trafficking, and the disassembly of protein complexes. These compounds often target specific domains within the VCP enzyme, allosterically promoting ATP hydrolysis and, consequently, accelerating its unfolding and extraction functions. As a result, VCP activators can impact cellular processes such as endoplasmic reticulum-associated degradation (ERAD), ubiquitin-proteasome system-mediated protein degradation, and autophagy, all of which are crucial for maintaining cellular homeostasis.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might enhance VCP expression by activating SIRT1, which has been shown to be involved in protein homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may increase VCP levels by modulating cellular stress responses, thus aiding in protein quality control. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can potentially elevate VCP expression by activating antioxidant response elements in cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to modulate proteostasis, possibly influencing VCP expression to maintain cellular protein balance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane might induce VCP expression through its role in activating the Nrf2 pathway, which is crucial for proteostasis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin can potentially upregulate VCP as part of its role in extending lifespan and enhancing cellular homeostasis. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
Trehalose might influence VCP expression through its role in autophagy and protein quality control. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may elevate VCP levels by impacting cellular signaling pathways related to neuroprotection. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin can potentially enhance VCP expression as part of its role in cellular metabolism and longevity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN might increase VCP levels by activating sirtuins, which play a critical role in cellular homeostasis. | ||||||