Molecular structure of β-Nicotinamide mononucleotide, CAS Number: 1094-61-7
β-Nicotinamide mononucleotide (CAS 1094-61-7)
See product citations (4)
Alternate Names:
β-NMN; β-Nicotinamide ribose monophosphate
Application:
β-Nicotinamide mononucleotide is a product of the eNAMPT reaction and a NAD+ intermediate
CAS Number:
1094-61-7
Purity:
≥95%
Molecular Weight:
334.22
Molecular Formula:
C11H15N2O8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
β-Nicotinamide mononucleotide (CAS 1094-61-7) References
- β-nicotinamide mononucleotide (NMN) production in Escherichia coli. | Marinescu, GC., et al. 2018. Sci Rep. 8: 12278. PMID: 30115969
- Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock. | Sims, CA., et al. 2018. JCI Insight. 3: PMID: 30185676
- Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure. | Pottorf, T., et al. 2018. Neurochem Int. 121: 86-97. PMID: 30278188
- Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome. | Liang, H., et al. 2019. Toxicol Appl Pharmacol. 362: 20-27. PMID: 30292833
- CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves. | Johnson, S., et al. 2018. NPJ Aging Mech Dis. 4: 10. PMID: 30416740
- Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism. | Klimova, N. and Kristian, T. 2019. Neurochem Res. 44: 2280-2287. PMID: 30661231
- Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. | Poddar, SK., et al. 2019. Biomolecules. 9: PMID: 30669679
- Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice. | Klimova, N., et al. 2019. J Neurosci Res. 97: 975-990. PMID: 30801823
- Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017. | Hasegawa, K. 2019. Clin Exp Nephrol. 23: 987-994. PMID: 30859351
- Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide. | Bertoldo, MJ., et al. 2018. Hum Reprod Open. 2018: hoy010. PMID: 30895251
- Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. | Song, J., et al. 2019. Cell Death Dis. 10: 336. PMID: 31000692
- Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. | Tarantini, S., et al. 2019. Redox Biol. 24: 101192. PMID: 31015147
- Slc12a8 is a nicotinamide mononucleotide transporter. | Grozio, A., et al. 2019. Nat Metab. 1: 47-57. PMID: 31131364
- Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence. | Lukacs, M., et al. 2019. Exp Neurol. 320: 112961. PMID: 31136762
- Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. | Kiss, T., et al. 2019. Geroscience. 41: 619-630. PMID: 31144244
Inhibitor of:
ATP5SL, CKMT1A, MCART2, MFF, MYG1, PARL, QIL1, SESN2, and TMEM70.Activator of:
β-1,3-Gal-T5, β3Gn-T2, 1700009C05Rik, 2400001E08Rik, 2810022L02Rik, 4930430F08Rik, Aacs, AARS2, ABCB8, ACOT12, AK8, ALDH1L2, ALG-2, ALG12, Apg-1, apoOL, APOP1, ARH3, ARL17, ART1, ART2A, ART2B, Arylsulfatase G, ASPHD1, ASRGL1, ATAD1, ATAD3B, ATAD4, Atg9b, ATPAF1, ATR2, Bcl-rambo, BFZB, BMAL2, Bpifb9a, BRCC2, BTBD1, C14orf43, C20orf194, C20orf3, C5orf21, C5orf33, C8orf38, C8orf45, C8orf46, C8orf48, C8orf5, C8orf58, C8orf68, C8orf74, CAF-1 p60, CASKIN2, Caytaxin, CCDC25, CDK2AP2, CEP164, CEP192, CEPT1, CHCHD4, CHCHD6, CHMP1B, CHMP4A, CKMT1, COMMD4, cortexin 3, COX10, COX7c, CRIP2, CUEDC1, DBC-2, DDX38, DGUOK, DHRS2, DHRS4, DHTKD1, DNA pol γ2, ECHDC3, EEPD1, EG546368, EP58, ERAB, ERAL1, Eso-1, FAM105A, FAM13C1, FAM161A, FAM163A, FOXRED1, FSIP1, FUNDC2, FYCO1, GβL, GHITM, Gm1381, Gm1679, Gm757, GNPDA1, golgin 45, GP-39, Grim19, GTPBP3, HEI10, hMLH3, HtrA2, ICAD, IFT52, IMMP1L, IMMP2L, KIAA1244, KNDC1, LACTB, LIMP III, LIPT2, LOC100041273, LOC55908, LOC644264, MacroH2A2, MAP17, MCT7, MDH2, Metaxin 1, METT11D1, Mfn2, MGC42105, Mitofilin, MMGT1, MondoA, MRM1, MRP-63, MRP-L10, MRP-L11, MRP-L12, MRP-L14, MRP-L15, MRP-L37, MRP-L41, MRP-L43, MRP-L46, MRP-L54, MRP-L55, MRP-L9, MRP-S21, MRP-S23, MRP-S30, MRP-S36, MRP-S6, MRRF, MTMR9, MTO1, mtTFA, NADK, NANS, NARG1, NBS1, NDUFB10, NDUFB5, NDUFB8, NDUFC1, NIPSNAP3B, Nir3, NMNAT-2, NT5C2, NT5C3L, Nuak1, NUDT13, NUDT4, NUDT8, nyctalopin, NYGGF4, PACRG, PADI2, PANK3, PARP S, PARP-12, PARP-3, PARP-7, PARP-9, PARS2, PDSS2, PHYHIPL, PICT-1, PIF1, PIWIL4, PLAC8, PNP2, POC5, POFUT2, Potefam3e, PRLH, PSAT1, QIL1, QTRT1, RBQ-1, RECS1, RED2, REEP1, resistin-like α, RNF121, RPA40, RPUSD2, SAMC, SAS-4, SCO2, SFXN5, SIM1, SLC25A29, SLC25A35, SLC25A36, SLC25A42, SLC25A44, SLC25A48, SLC35D1, SMC5, Spartin, Speriolin, SUV3, TAMM41, TEN1, TERE1, Tim13A/B, Tim13B, Tim22, TMEM135, TMEM192, TMEM60, TMEM70, Tom34, TRBP2, UAP1, UBE2F, V3R 3, VCP, VEGF-B, VPS13D, Vps34, WBP2, WIPI-1, X11, X11β, XRCC6BP1, YME1L1, ZFOC1, and ZnT-8.Substrate of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Nicotinamide mononucleotide, 25 mg | sc-212376 | 25 mg | $92.00 | |||
β-Nicotinamide mononucleotide, 100 mg | sc-212376A | 100 mg | $269.00 | |||
β-Nicotinamide mononucleotide, 1 g | sc-212376B | 1 g | $337.00 | |||
β-Nicotinamide mononucleotide, 2 g | sc-212376C | 2 g | $510.00 | |||
β-Nicotinamide mononucleotide, 5 g | sc-212376D | 5 g | $969.00 |