Vangl2 Inhibitors
Vangl2 inhibitors pertain to a class of chemical compounds that specifically target and inhibit the activity of the Vangl2 protein, a crucial component in the Wnt signaling pathway. Vangl2, also known as Van Gogh-like 2, plays a pivotal role in cellular processes related to the establishment of planar cell polarity (PCP), which is vital for the proper orientation and alignment of cells within a tissue plane. The protein is evolutionarily conserved across various species, underscoring its importance in developmental processes. Vangl2's involvement in the PCP pathway is intricate, as it interacts with multiple other proteins and signaling molecules to modulate cell behavior, influencing aspects such as directional cell movement, orientation of cilia, and the asymmetric development of certain organs.
The development of Vangl2 inhibitors has garnered interest due to the protein's integral role in these cellular processes. These inhibitors are typically small molecules designed to bind to the Vangl2 protein, thereby modulating its activity or stability, and subsequently impacting the PCP signaling cascade. The inhibition of Vangl2 can lead to alterations in cell behavior and tissue organization, given the protein's central role in directing cell polarity and orientation. By manipulating Vangl2 activity, these inhibitors have the potential to impact a variety of cellular processes and influence the overall development and maintenance of tissue architecture. However, it is crucial to note that due to the complexity of the PCP pathway and the multitude of interactions Vangl2 engages in, the precise effects of inhibiting this protein can be highly context-dependent, varying based on factors such as cell type, developmental stage, and the presence of other signaling molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog, which can incorporate into DNA and RNA. It is known to inhibit DNA methyltransferases, leading to DNA demethylation, potentially affecting gene expression including that of Vangl2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting these enzymes, it can alter the chromatin structure and potentially decrease the expression of specific genes, including Vangl2. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid has histone deacetylase inhibitory activity, leading to changes in chromatin structure and potentially affecting gene expression, including the downregulation of Vangl2. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor. It can demethylate DNA without causing cytotoxicity, which might result in the alteration of gene expression, including the inhibition of Vangl2. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is another cytidine analog that can incorporate into DNA. It primarily targets DNA methyltransferases, potentially leading to DNA demethylation and reduced Vangl2 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a phytoestrogen and has been shown to have DNA demethylating properties. It might alter the expression of various genes, including potentially inhibiting the expression of Vangl2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has a range of biological activities, including the ability to modulate epigenetic changes. It could potentially downregulate the expression of certain genes, such as Vangl2, via these mechanisms. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid has been shown to have histone acetyltransferase inhibitory activity, which could lead to changes in chromatin structure and a potential decrease in the expression of genes like Vangl2. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a well-known histone deacetylase inhibitor. By altering histone acetylation levels, it could potentially affect the expression of various genes, possibly including Vangl2. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been shown to have various biological activities. It has the potential to induce epigenetic changes, potentially leading to altered expression of certain genes, such as Vangl2. | ||||||