Vangl2 Activators
The term Vangl2 Activators refers to a class of chemical compounds that can modulate the activity of the Vangl2 protein. Vangl2, or Van Gogh-like 2, is a core component of the planar cell polarity (PCP) pathway. This pathway is responsible for the coordinated orientation of cells within the plane of epithelial sheets, and the activity of Vangl2 is crucial for ensuring proper cellular orientation and tissue morphogenesis. Vangl2 itself is a transmembrane protein, and its activity can be influenced by various biochemical interactions. Activators of this protein typically facilitate or amplify its function, ensuring that the PCP pathway functions optimally.
Chemically, Vangl2 activators can belong to diverse structural classes, ranging from small molecules to peptides. Their mechanism of action can vary, but most work either by binding directly to the Vangl2 protein, thereby stabilizing its active form, or by influencing upstream or downstream signaling molecules that in turn modulate Vangl2 activity. The molecular design and discovery of Vangl2 activators often involve detailed structure-activity relationship studies, high-throughput screening, and computational modeling. These compounds are characterized by their ability to selectively enhance the activity of Vangl2 without significantly influencing other proteins or pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays roles in cell development and differentiation. It could potentially influence pathways associated with the PCP pathway and induce Vangl2 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects the Wnt signaling pathway, which intersects with the PCP pathway. This interaction might lead to an influence on Vangl2 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, which elevates cyclic AMP levels. The increased cAMP could influence cellular pathways that regulate Vangl2 expression. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
Inhibitors of GSK3β can activate the Wnt/β-catenin signaling pathway. This activation might influence the PCP pathway, potentially affecting Vangl2 expression. | ||||||
2-Methyl-4-isothiazolin-3-one | 2682-20-4 | sc-230522 sc-230522A sc-230522B sc-230522C | 5 g 100 g 500 g 1 kg | $94.00 $195.00 $520.00 $900.00 | ||
Methylisothiazolinone has been shown in certain studies to modulate expression of genes involved in cell differentiation and might, therefore, influence Vangl2 expression indirectly. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo is a Wnt pathway inhibitor. Its activity on the Wnt pathway might indirectly affect the PCP pathway and Vangl2 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor and might influence multiple cellular pathways, potentially leading to modulation of Vangl2 expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a TGF-β receptor kinase inhibitor. By modulating TGF-β signaling, it might indirectly affect pathways associated with Vangl2 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has a broad range of bioactivities, including modulation of signaling pathways, potentially affecting Vangl2 expression. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
Biochanin A, an isoflavone, is known to influence various cellular pathways, and could potentially modulate Vangl2 expression through its action on these pathways. | ||||||