V1RI4 inhibitors are a class of chemical compounds designed to selectively bind to and inhibit the function of a specific type of receptor known as V1RI4. The V1RI4 receptor is part of a larger family of receptors that play a critical role in the regulation of various physiological processes within the body. These inhibitors are typically characterized by their high specificity, as they are tailored to interact with the unique structural features of the V1RI4 receptor. By doing so, they effectively block the receptor's ability to bind to its natural ligands, which are the molecules that normally activate the receptor. The design and development of V1RI4 inhibitors involve a deep understanding of the molecular architecture of the receptor, which includes knowledge of the active site, the binding affinity, and the conformational changes that occur upon ligand interaction.
The development of V1RI4 inhibitors often relies on advanced techniques in medicinal chemistry, computational modeling, and biochemistry. Scientists utilize structure-activity relationship (SAR) studies to refine the efficacy and selectivity of these inhibitors. By making systematic modifications to the chemical structure of these compounds, researchers can determine the impact on the interaction with the V1RI4 receptor and make iterative improvements. Additionally, the use of computational methods allows for the virtual screening of compound libraries to identify potential inhibitors, which can then be synthesized and tested in experimental settings. The inhibitors may vary in their structure, ranging from small molecules to more complex organic compounds, and are often the product of extensive synthetic chemistry efforts aimed at creating stable, high-affinity inhibitors that can effectively interact with the V1RI4 receptor. The exact nature of these chemical interactions is crucial, as it dictates the efficiency with which these inhibitors can bind to the receptor and produce the desired inhibitory effect.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor. Since V1RI4 is a G protein-coupled receptor involved in olfactory signal transduction, EGFR inhibition can downregulate pathways that might crosstalk with GPCR signaling, leading to reduced V1RI4 functional activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Src family kinases can phosphorylate GPCR receptors; inhibition of these kinases can prevent phosphorylation and subsequent internalization of V1RI4, thus decreasing its signaling efficacy. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K can be activated downstream of GPCRs, including V1RI4. Inhibition of PI3K would likely decrease the downstream signaling activities of V1RI4. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go 6983 is a protein kinase C (PKC) inhibitor. PKC is downstream of GPCR activation, and V1RI4 signaling involves PKC. Thus, inhibiting PKC can decrease V1RI4-mediated responses. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. Rho-associated kinases can be involved in GPCR signaling; thus, inhibition of ROCK might attenuate the downstream effects of V1RI4 activation. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB 202190 is a p38 MAPK inhibitor. p38 MAPK can be involved in GPCR signaling, and inhibiting p38 MAPK may lead to decreased signaling through V1RI4. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is a nitric oxide synthase inhibitor. Nitric oxide can modulate GPCR signaling, and its inhibition may reduce V1RI4 signaling by decreasing receptor sensitivity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is a myosin light chain kinase inhibitor. Inhibition of myosin light chain kinase can lead to reduced contractility and cellular responses that are sometimes linked to GPCR signaling, potentially affecting V1RI4 activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole is a CYP3A4 inhibitor. Cytochrome P450 enzymes can metabolize signaling molecules that interact with GPCRs, and inhibition of CYP3A4 may alter the signaling landscape in which V1RI4 operates. | ||||||