UTP14B Activators
Chemical activators of UTP14B can induce stress in various cellular pathways, leading to an increased demand for ribosome biogenesis quality control, where UTP14B plays a critical role. 6-Aminonicotinamide (6-AN) is known to inhibit the pentose phosphate pathway, altering the NADP+/NADPH ratio and consequently increasing the need for ribosome biogenesis quality control mechanisms, thereby activating UTP14B. Similarly, Cycloheximide disrupts protein synthesis by blocking the translocation step, causing ribosome stalling and necessitating the involvement of UTP14B in the surveillance and rescue of defective ribosomal particles. Puromycin and Anisomycin disrupt translation by causing premature chain termination and interfering with peptide chain elongation, respectively. These actions can lead to an accumulation of defective ribosomal particles, which in turn activates UTP14B's role in ribosome-associated quality control processes. Homoharringtonine also inhibits the initiation and elongation phases of protein synthesis, potentially leading to ribosome stalling and subsequent activation of UTP14B.
Moreover, agents such as Tunicamycin, Dithiothreitol, Thapsigargin, and Brefeldin A induce different types of cellular stress, all of which can lead to an enhanced role for UTP14B in maintaining ribosome function. Tunicamycin blocks N-linked glycosylation, causing stress in the endoplasmic reticulum (ER), while Dithiothreitol disrupts disulfide bonds, causing oxidative stress and misfolded proteins. Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, leading to ER stress. Brefeldin A causes ER stress by disrupting ER-Golgi transport. All these stressors can activate UTP14B to address the heightened need for ribosome biogenesis quality control. Emetine and Chloramphenicol, although through different mechanisms, inhibit elongation and termination steps or block peptidyl transferase activity, respectively, leading to ribosomal stalling and further activating UTP14B's role. Lastly, MG132 impedes proteasome function, leading to an accumulation of misfolded proteins and subsequently necessitating the activation of UTP14B within the ribosome-associated quality control complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $153.00 $390.00 | 3 | |
6-AN (6-Aminonicotinamide) inhibits the pentose phosphate pathway, leading to alterations in cellular NADP+/NADPH ratio. This perturbation in redox balance can increase the need for ribosome biogenesis quality control mechanisms, potentially increasing the demand for and thereby activating UTP14B's role in ribosome biogenesis and RNA processing. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks the translocation step in protein synthesis, causing ribosome stalling. This can lead to an increased requirement for ribosome-associated quality control, potentially activating UTP14B's function in the surveillance and rescue of defective ribosomal particles. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin causes premature chain termination during translation by acting as an analog to aminoacyl-tRNA. This may lead to an accumulation of defective ribosomal particles, potentially activating UTP14B's involvement in ribosome-associated quality control processes. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Homoharringtonine inhibits the initiation and elongation phases of protein synthesis, potentially leading to ribosome stalling and activation of UTP14B's function as part of the ribosome quality control complex. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, stressing the ER and potentially increasing the requirement for ribosome quality control, which may activate UTP14B's role in ribosome biogenesis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to ER stress which may increase the need for ribosome biogenesis quality control, potentially activating UTP14B. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts ER-Golgi transport, causing ER stress and potentially increasing the requirement for ribosomal quality control mechanisms, which could activate UTP14B's function. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin interferes with peptide chain elongation during protein synthesis, potentially leading to ribosomal stalling and activating UTP14B's role in ribosome biogenesis and quality control processes. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine inhibits elongation and termination steps of protein synthesis, potentially causing ribosomal stalling and activating UTP14B's role in the ribosome quality control pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 inhibits proteasomes, leading to accumulation of misfolded proteins and potentially activating UTP14B as part of the ribosome-associated quality control complex to manage defective ribosomal particles. | ||||||