Molecular structure of 6-Aminonicotinamide, CAS Number: 329-89-5
6-Aminonicotinamide (CAS 329-89-5)
See product citations (3)
Alternate Names:
6-Aminopyridine-3-carboxamide
Application:
6-Aminonicotinamide is a PGD inhibitor and apoptosis inducer
CAS Number:
329-89-5
Purity:
≥98%
Molecular Weight:
137.14
Molecular Formula:
C6H7N3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration. 6-Aminonicotinamide′s precise mechanism of action remains largely unexplored, yet it is thought to function as a nicotinamide adenine dinucleotide (NAD) pathway agonist, which plays a vital role in numerous cellular activities like energy metabolism, DNA repair, and apoptosis. Furthermore, the compound inhibits enzymes such as histone deacetylases (HDACs), DNA methyltransferases (DNMTs), and protein kinase C (PKC). These enzymes are instrumental in governing gene expression, potentially accounting for the impact of 6-Aminonicotinamide on cell growth and differentiation.
6-Aminonicotinamide (CAS 329-89-5) References
- Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation. | Belfi, CA., et al. 1999. Biochem Biophys Res Commun. 257: 361-8. PMID: 10198218
- Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart. | Zuurbier, CJ., et al. 2004. Cardiovasc Res. 62: 145-53. PMID: 15023561
- Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. | Penkowa, M., et al. 2004. J Neurosci Res. 77: 35-53. PMID: 15197737
- 6-Aminonicotinamide selectively causes necrosis in reactive astroglia cells in vivo. Preliminary morphological observations. | Politis, MJ. 1989. J Neurol Sci. 92: 71-9. PMID: 2527969
- Pathology of 6-aminonicotinamide toxicosis in the rabbit. | Render, JA., et al. 1985. Food Chem Toxicol. 23: 795-803. PMID: 2931336
- Influence of 6-aminonicotinamide (6AN) on Leishmania promastigotes evaluated by metabolomics: Beyond the pentose phosphate pathway. | Almugadam, SH., et al. 2018. Chem Biol Interact. 294: 167-177. PMID: 30170107
- Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production. | Ren, F., et al. 2019. EBioMedicine. 49: 232-246. PMID: 31680002
- In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis. | Xin, Q., et al. 2020. Vet Res. 51: 29. PMID: 32101153
- Blockade of Cellular Energy Metabolism through 6-Aminonicotinamide Reduces Proliferation of Non-Small Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress. | Kaushik, N., et al. 2021. Biology (Basel). 10: PMID: 34827081
- Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. | Lange, K. and Proft, ER. 1970. Naunyn Schmiedebergs Arch Pharmakol. 267: 177-80. PMID: 4394804
- 6-Aminonicotinamide-resistant mutants of Salmonella typhimurium. | Hughes, KT., et al. 1983. J Bacteriol. 154: 1126-36. PMID: 6222034
- 6-Aminonicotinamide-induced hydrocephalus in suckling mice. | Aikawa, H., et al. 1984. J Neuropathol Exp Neurol. 43: 511-21. PMID: 6236288
- Inhibitory effect of 6-aminonicotinamide on the renal transport of para-aminohippurate in the rat. | Sudo, J., et al. 1984. Jpn J Pharmacol. 36: 491-8. PMID: 6241269
- Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. | Street, JC., et al. 1997. Cancer Res. 57: 3956-62. PMID: 9307279
- 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin. | Budihardjo, II., et al. 1998. Clin Cancer Res. 4: 117-30. PMID: 9516960
Inhibitor of:
CNTNAP3, CUL-4A, DHRS12, EG240549, EG433182, EG619597, G6pd2, GFOD1, GLOD4, Glucose-6-Phosphate Dehydrogenase, H6PD, PFKP, PGD, PGLS, PYGM, rcRPE, TKTL2, Transketolase, VibH, and ZMAT2.Activator of:
ART2B, EG433182, EG546638, FBXW26, Ferroportin-1, OTUB1, and UTP14B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Aminonicotinamide, 1 g | sc-278446 | 1 g | $156.00 | |||
6-Aminonicotinamide, 5 g | sc-278446A | 5 g | $398.00 |