UTP14B Inhibitors
UTP14B inhibitors are a class of chemical compounds that specifically target the catalytic activity of the UTP14B protein, which is part of the ribosome biogenesis regulatory pathway. Ribosome biogenesis is a fundamental cellular process involving the production of ribosomes, the molecular machines responsible for protein synthesis within cells. The UTP14B protein plays a crucial role in the maturation of the 18S rRNA, a key component of the small ribosomal subunit. By inhibiting UTP14B, these compounds can affect the production and assembly of ribosomes, thus impacting the overall protein synthesis machinery. The specificity of UTP14B inhibitors lies in their ability to bind to the active sites or allosteric sites of the UTP14B protein, thereby hindering its function.
The molecular design of UTP14B inhibitors is based on the structural understanding of the UTP14B protein, which includes knowledge of the active site geometry and the identification of potential binding pockets. These inhibitors are synthesized through a variety of chemical strategies, aiming to achieve a high affinity and selectivity for the UTP14B protein. The development of UTP14B inhibitors involves meticulous structure-activity relationship (SAR) studies, which help in refining the inhibitor compounds to maximize their interaction with the UTP14B protein while minimizing off-target effects. Inhibitors of UTP14B include small molecules that can traverse cellular membranes to reach intracellular targets, as well as larger biomolecules that may interfere with UTP14B protein-protein interactions. The chemical properties of these inhibitors are fine-tuned to ensure stability, adequate half-life, and suitable pharmacokinetic profiles for their interaction with UTP14B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically binds to FKBP12 and the resulting complex binds to and inhibits the mTOR pathway. Since UTP14B is involved in ribosome biogenesis, which is a process downstream of mTOR signaling, the inhibition of mTOR can lead to a decrease in ribosome biogenesis and thus a reduction in UTP14B function. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As an antimetabolite that interferes with RNA synthesis, 5-Fluorouracil can disrupt the synthesis of UTP14B by affecting the RNA polymerase needed for its transcription. This results in decreased levels of UTP14B protein through reduced transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates DNA and prevents RNA synthesis by inhibiting RNA polymerase. This directly decreases the transcription of the gene coding for UTP14B, resulting in lower levels of the UTP14B protein. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit RNA polymerase I, II, and III. Since UTP14B is a ribosomal protein, its expression is closely tied to RNA polymerase I activity. Inhibition of this polymerase can therefore decrease UTP14B levels. | ||||||
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
As a selective inhibitor of protein kinase CK2, CX-4945 can disrupt various signaling pathways, including those related to ribosome assembly. This could indirectly affect the functional activity of UTP14B by disrupting its incorporation into the ribosome. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, thereby triggering the unfolded protein response and potentially reducing the synthesis of ribosomal proteins such as UTP14B as part of a global downregulation of protein synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus possibly affecting the synthesis and function of ribosomal proteins like UTP14B. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that inhibits eukaryotic protein synthesis. By blocking peptide bond formation, it could decrease the synthesis of ribosome-associated proteins, including UTP14B. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
An inhibitor of eukaryotic initiation factor 4A (eIF4A), silvestrol disrupts the initiation of mRNA translation. This can lead to a reduction in the synthesis of proteins such as UTP14B. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine is an alkaloid that inhibits protein synthesis by blocking the elongation step of translation on ribosomes. This results in a decreased level of ribosomal proteins, including UTP14B, due to inhibition of their synthesis. | ||||||