UST1R Inhibitors
Chemical inhibitors of UST1R include a variety of compounds that interfere with the protein's function through different mechanisms. Quercetin can inhibit UST1R by stabilizing cell membranes and blocking the transporter's substrate access. Genistein, with its ability to inhibit tyrosine kinases, can alter the phosphorylation state of proteins that regulate UST1R, leading to an inhibition of the protein's transport function. Verapamil's role as a calcium channel blocker translates into an altered intracellular calcium level, which can affect the function of transporters like UST1R, while Probenecid competes for transport sites on UST1R, potentially inhibiting the protein by blocking substrate access. Indomethacin brings about a reduction in intracellular cAMP levels, which in turn can lead to the inhibition of UST1R's transport activity, and Phloretin can inhibit UST1R by interfering with the protein's ability to translocate substrates across the cell membrane.
Other inhibitors such as DIDS function by covalently modifying UST1R or its regulatory components, impairing its activity. Amiloride can inhibit UST1R by affecting the electrochemical gradient that is crucial for the function of many transporters. Niflumic acid, by altering ion fluxes and membrane potentials, can inhibit UST1R's activity. Similarly, Sulfinpyrazone can inhibit UST1R by either competing for substrate binding or interfering with the regulatory mechanisms of the transporter. Tamoxifen can disrupt the membrane fluidity and organization of lipid rafts, which are essential for the function of membrane transporters like UST1R. Lastly, Furosemide can inhibit UST1R by competing with substrates or altering ion gradients that are necessary for UST1R's function. Each of these chemicals employs a distinct mode of action to inhibit the transport activity of UST1R, which is central to its role in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can inhibit UST1R by stabilizing cell membranes and preventing the uptake of molecules that UST1R may transport. This flavonoid has been shown to inhibit glucose transporters, suggesting a potential to inhibit similar transport proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, is known to inhibit tyrosine kinases. UST1R, being a transporter that might be regulated by phosphorylation, could be functionally inhibited as genistein alters the phosphorylation state of proteins involved in transporter regulation. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can inhibit UST1R by altering intracellular calcium levels, which can affect the function of various transporters and potentially inhibit the transport activity of UST1R. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid acts as an inhibitor of organic anion transporters and can inhibit UST1R by competing for the transport sites, thus potentially blocking the substrate access to UST1R. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a nonsteroidal anti-inflammatory drug that can inhibit UST1R by reducing the intracellular cAMP levels, which may regulate the activity of some transporters, thereby inhibiting UST1R's transport function. | ||||||
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin is a dihydrochalcone that inhibits various glucose transporters and could inhibit UST1R by interfering with the transporter's ability to move its substrates across the cell membrane. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride, a potassium-sparing diuretic, can inhibit UST1R by modulating the electrochemical gradient across cell membranes, which is essential for the function of various transporters. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is known to inhibit chloride channels and can inhibit UST1R by altering ion fluxes and membrane potentials, potentially affecting the transporter's activity. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $39.00 $92.00 | 2 | |
Sulfinpyrazone is a uricosuric agent that can inhibit UST1R by competing for substrate binding sites or by interfering with the regulatory mechanisms of the transporter. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, an estrogen receptor modulator, can inhibit UST1R by disrupting membrane fluidity and lipid rafts, which are known to be important for the proper functioning of membrane transporters. | ||||||