Probenecid CAS: 57-66-9
MF: C13H19NO4S
MW: 285.36
An inhibitor of several ABC-transporters of the subfamily ABCC or MRP.

Probenecid (CAS 57-66-9)

Probenecid | CAS 57-66-9 is rated 5.0 out of 5 by 2.
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Alternate Names: p-(Dipropylsulfamoyl)benzoic acid
Application: Probenecid is an inhibitor of several ABC-transporters of the subfamily ABCC or MRP
CAS Number: 57-66-9
Purity: ≥98%
Molecular Weight: 285.36
Molecular Formula: C13H19NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Probenecid is an inhibitor of MRP1 (multidrug resistance-associated proteins). This compound blocks the active site of MRP1 and prevents cellular efflux of other active compounds, enhancing their effectiveness by allowing them to remain in the cytoplasm. Probenecid is an inhibitor of Pannexin-1.

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), solutions of alkali hydroxides,, ethanol (100 mM), acetone, chloroform, sodium hydroxide (1 M), DMSO (100 mM), methanol, dilute acids (practically insoluble), dilute alkalies, and ether (slightly soluble).
Storage :
Store at room temperature
Melting Point :
197.8-200° C
Boiling Point :
437.96° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Solute carrier family 22 member 12: IC50 = 8.64 (human)
Ki Data :
Solute carrier family 22 member 6: Ki= 6.4 µM (mouse); Solute carrier family 22 member 20: Ki= 8.4 µM (mouse); UDP-glucuronosyltransferase 1-7: Ki= 96 µM (human)
pK Values :
pKa: 3.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DG9400000
PubChem CID :
4911
Merck Index :
14: 7754
MDL Number :
MFCD00038402
EC Number :
200-344-3
Beilstein Registry :
2815775
SMILES :
CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(O)=O

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Certificate of Analysis

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Probenecid (CAS 57-66-9)  Product Citations

See how others have used Probenecid (CAS 57-66-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 31235574  Park, SJ.|Kim, Y.|Yang, SM.|Henderson, MJ.|Yang, W.|Lindahl, M.|Urano, F.|Chen, YM.| et al. 2019. Proc. Natl. Acad. Sci. U.S.A. 116: 14154-14163.

PMID: # 28377398  Petes, C.|Wynick, C.|Guzzo, C.|Mehta, D.|Logan, S.|Banfield, BW.|Basta, S.|Cooper, A.|Gee, K.| et al. 2017. J. Leukoc. Biol. 102: 83-94.

PMID: # 27926506  Su, L. et al. 2017. Oncotarget. 8: 2617-2627.

PMID: # 28739698  Park, Y.|Son, JY.|Lee, BM.|Kim, HS.|Yoon, S.| et al. 2017. Anticancer Res. 37: 4139-4146.

PMID: # 27600508  White, RC. et al. 2016. Infect. Immun. 84: 3313-3327.

PMID: # 26661076  Ajithkumar, GS. et al. 2016. Cardiovasc. Toxicol. 16: 390-405.

PMID: # 25750433  Vogel, SZ. et al. 2015. Journal of immunology (Baltimore, Md. : 1950). 194: 3136-46.

PMID: # 25868858  Thuringer, D. et al. 2015. Oncotarget. 6: 10267-83.

PMID: # 26209696  Adada, MM. et al. 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29: 4654-69.

PMID: # 23712819  Zou, P. et al. 2013. J Pharm Sci. 102: 2837-50.

Citations 1 to 10 of 13 total
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Rated 5 out of 5 by from Great reagent I successfully used this to help maintain CCF2-AM substrate loaded within human and murine macrophages. Would recommend this product for assaying beta-lactamase activity with CCF2 and CCF4 substrates.
Date published: 2017-08-26
Rated 5 out of 5 by from Ikeda et al Ikeda et al. (PubMed ID 26373208) used probenecid to increase fluorescein s permeability coefficient by inhibiting multidrug resistant-associated proteins. -SCBT Publication Review
Date published: 2015-07-02
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