Molecular structure of (±)-Sulfinpyrazone, CAS Number: 57-96-5
(±)-Sulfinpyrazone (CAS 57-96-5)
See product citations (2)
Alternate Names:
1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione
Application:
(±)-Sulfinpyrazone is a free radical scavenger that inhibits organic anion transporters
CAS Number:
57-96-5
Purity:
≥98%
Molecular Weight:
404.48
Molecular Formula:
C23H20N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Sulfinpyrazone, also known as Sulfinpyrazone, is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of (±)-Sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).
(±)-Sulfinpyrazone (CAS 57-96-5) References
- Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. | Evers, R., et al. 2000. Br J Cancer. 83: 375-83. PMID: 10917554
- Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | Ito, K., et al. 2001. J Biol Chem. 276: 38108-14. PMID: 11500505
- Free radical scavenging properties of sulfinpyrazone. | Yang, ML., et al. 2002. Free Radic Res. 36: 685-93. PMID: 12180194
- UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines. | Dumitriu, IE., et al. 2003. Strahlenther Onkol. 179: 564-70. PMID: 14509956
- Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes. | Korcok, J., et al. 2003. Brain Res. 993: 201-7. PMID: 14642847
- Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) 'probes' for human udp-glucuronosyltransferases. | Uchaipichat, V., et al. 2006. Drug Metab Dispos. 34: 449-56. PMID: 16381668
- Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9. | Kerdpin, O., et al. 2006. Drug Metab Dispos. 34: 1950-3. PMID: 16985098
- MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer. | Oguri, T., et al. 2008. Mol Cancer Ther. 7: 1150-5. PMID: 18445659
- Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma. | Giuliani, AL., et al. 2014. PLoS One. 9: e107224. PMID: 25226385
- Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity. | Lorenzon, P., et al. 2015. J Neurosci. 35: 146-60. PMID: 25568110
- Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal. | Pierce, MR., et al. 2015. J Neurosci Res. 93: 1881-90. PMID: 26366722
- Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease. | Ortner, NJ., et al. 2017. J Neurosci. 37: 6761-6777. PMID: 28592699
- Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea. | Mazzarda, F., et al. 2020. Lab Chip. 20: 3011-3023. PMID: 32700707
- Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice. | Dematteis, G., et al. 2020. Cell Death Dis. 11: 645. PMID: 32811809
- Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. | Harker, LA., et al. 1983. Circ Res. 53: 731-9. PMID: 6640860
Inhibitor of:
ABCF3, ADO, CPS II, CTL3, Cyp2c65, CYP2C9, CYP2J11, CYP4A12A, CYP4F11, Cyp4f15, GlcAT-S, Glut9, HGD, OATP, OATP-E, Oatp5, Protein Z, PRPS2, PT, QAPRTase, RCL, SLC17A4, Slc22a27, SLC22A29, SLC26A6, SLC37A3, SVCT1, SVCT3, TRPT1, UGT, UGT1A3, UGT1A9, UGT2B, UGT2B15, UGT2B17, UGT2B36, UGT3A1, UGT3A2, UGT8, UGTREL1, UST1R, and Xanthine Oxidase.Activator of:
FAM13A1.Substrate of:
MRP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Sulfinpyrazone, 1 g | sc-202822 | 1 g | $39.00 | |||
(±)-Sulfinpyrazone, 5 g | sc-202822A | 5 g | $92.00 |