Molecular structure of Phloretin, CAS Number: 60-82-2
Phloretin (CAS 60-82-2)
See product citations (13)
Alternate Names:
β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Application:
Phloretin is a calcium channel protein inhibitor
CAS Number:
60-82-2
Purity:
≥98%
Molecular Weight:
274.26
Molecular Formula:
C15H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Phloretin is an inhibitor of calcium channel protein, MCT1, MCT2, and PKC. It is the major polyphenol that can befound in apples. Phloretin is a dihydrochalcone, a type of phenolic compound. Phloretin influences the permeability of cellular membranes to certain substances, making it useful in the study of transport processes across biological membranes. In the realm of biochemical research, phloretin′s role in inhibiting glucose transporters and other membrane transport proteins offers insights into the mechanisms controlling nutrient uptake and metabolite exchange in cells.
Phloretin (CAS 60-82-2) References
- Interaction of phloretin with lipid monolayers: relationship between structural changes and dipole potential change. | Cseh, R. and Benz, R. 1999. Biophys J. 77: 1477-88. PMID: 10465758
- Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells. | Hassan, M., et al. 2007. Biochem Biophys Res Commun. 361: 208-13. PMID: 17658475
- Induction of apoptosis in HT-29 colon cancer cells by phloretin. | Park, SY., et al. 2007. J Med Food. 10: 581-6. PMID: 18158826
- [Phloretin induces apoptosis of BEL-7402 cells in vitro]. | Luo, H., et al. 2008. Nan Fang Yi Ke Da Xue Xue Bao. 28: 1249-51. PMID: 18676276
- In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter. | Wu, CH., et al. 2009. Int J Cancer. 124: 2210-9. PMID: 19123483
- Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling. | Kim, MS., et al. 2009. Ann N Y Acad Sci. 1171: 479-83. PMID: 19723092
- Inhibition of biological actions of 12-O-tetradecanoylphorbol-13-acetate by inhibitors of protein kinase C. | Tanaka, K., et al. 1986. Jpn J Cancer Res. 77: 1107-13. PMID: 3025144
- Phloretin as both a substrate and inhibitor of tyrosinase: Inhibitory activity and mechanism. | Chen, J., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 226: 117642. PMID: 31614273
- Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C. | Prevarskaya, N., et al. 1994. Mol Cell Neurosci. 5: 699-708. PMID: 7704445
- Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis [corrected]. | Koh, DS., et al. 1994. Neurosci Lett. 165: 167-70. PMID: 8015719
- Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. | Kitanaka, J., et al. 1993. J Neurochem. 60: 704-8. PMID: 8093482
- Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells. | Wang, X., et al. 1993. Biochem J. 290 (Pt 1): 249-58. PMID: 8439293
- Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats. | Mizuma, T. and Awazu, S. 1998. Biochim Biophys Acta. 1425: 398-404. PMID: 9795255
Inhibitor of:
4933425O20Rik, Ah Receptor, AKR7, apoL7b, AQP1, AQP12, AQP12A, AQP12B, AQP3, AQP6, AQP7, AQP8, band 3, BNC1, C2orf62, Calcium Channel Protein, CHST7, Contrin, EG433182, Embigin, ENO4, FAM22A, FBP, FCGBP_Fcgbp, FLJ22184, Galactose Mutarotase, GALT, Glut1, Glut10, Glut11, Glut12, Glut14, Glut2, Glut4, Glut5, Glut7, Glut8, Glut9, Glycophorin D, GLYCTK, GNPDA1, GSTM5, hnRNP E3, hornerin, HXK III, Krtap28-10, LHFPL2, LRRC8A, LRRC8B, LRRC8C, MCT1, MCT11, MCT13, MCT2, MFSD5, MFSD9, mKIAA0195, NaGLT1, Naglt1c, NEI, Neurophysin I, OATP-C, OR4C3, OR4D1, ORNT2, OSTβ, p36, PCSK9, PFKP, PGAM1, PKC, PXT1, rBAT, RDH10, RERGL, Sciellin, SCOCO, Sectm1b, Ser/Thr Protein Kinase, SGLT-3, SGLT-6, SHP, SLC-1, SLC10A6, SLC13A5, SLC25A44, SLC2A4RG, SLC35F4, SLC38A10, SLC43A1, SLC5 (solute carrier family 5; SLC5A), SLC5A12, SMAGP, SMCP, SNAT6, Snf1, SR-BI, SULT1A4, SULT2A2, SVCT1, SVCT2, SVCT3, T1R3, TAS1R (taste receptor; GPCR), THTR1, TKTL2, TMEM106C, TMEM117, TMEM151B, TMEM166, TMEM167, TMEM247, TMEM37, Trav12n-2, UGT3A1, UNC119B, UPIIIb, UST1R, UT-B, Vmn2r26, and ZPBP1.Activator of:
AQP12A, C9orf91, Crk I/II, ICE p20, KIR4.2, LRRC8D, LRRC8E, NaDC-1, OR2AK2, PDAP1, Slc16a5, SLC2A13, and xCT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phloretin, 200 mg | sc-3548 | 200 mg | $63.00 | |||
Phloretin, 1 g | sc-3548A | 1 g | $250.00 |