Niflumic acid (CAS 4394-00-7)

Usage :

Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.

Physical State :

Solid

Solubility :

Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25° C), and acetonitrile (~50 mg/ml).

Storage :

Store at room temperature

Melting Point :

203-204° C

Boiling Point :

~378.0° C at 760 mmHg (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.59 (Predicted)

IC50 :

Cox-2: IC₅₀ = 918 nM (human); Cox-1: IC₅₀ = 1.06 µM (human); GPR35: IC₅₀ = 1.28 µM (human); mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes: IC₅₀ = 8 µM; mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes: IC₅₀ = 8 µM

Ki Data :

Cox-2: K_i= 0.02 µM (sheep); Cox-1: K_i= 2 µM (sheep)

pK Values :

pK_a: 1.7 (Predicted), pK_b: 4.71 (Predicted)

WGK Germany :

3

RTECS :

QT2999100

PubChem CID :

Merck Index :

14: 6531

MDL Number :

MFCD00010569

EC Number :

224-516-2

SMILES :

C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F