USP49 Inhibitors
USP49 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of ubiquitin-specific peptidase 49 (USP49), an enzyme involved in the regulation of protein ubiquitination. USP49 is a deubiquitinating enzyme (DUB), meaning its primary role is to remove ubiquitin molecules from substrate proteins. This action is crucial in maintaining protein homeostasis, as ubiquitination typically marks proteins for degradation via the proteasome. By reversing this modification, USP49 can regulate protein stability and function. Inhibitors of USP49 disrupt its ability to cleave ubiquitin from target proteins, which can lead to altered cellular protein levels and affect processes such as transcription, DNA repair, and signal transduction.
Structurally, USP49 inhibitors are often designed to bind to the catalytic domain of the enzyme, specifically the region responsible for hydrolyzing the isopeptide bond between ubiquitin and its substrate. Some inhibitors may act by directly occupying the active site, while others might interfere with enzyme conformational changes necessary for its activity. The inhibition of USP49 provides valuable insights into the enzyme's role in cellular processes, particularly in understanding how deubiquitination influences the regulation of gene expression and protein turnover. These inhibitors are important tools for studying the ubiquitin-proteasome system, a critical regulatory network in cells, and for unraveling the specific contributions of USP49 in maintaining protein balance and orchestrating cellular functions. By inhibiting USP49, researchers can explore its involvement in broader cellular mechanisms like cell cycle progression, gene regulation, and protein quality control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This HDAC inhibitor could directly lead to increased acetylation of histones near the USP49 promoter, resulting in a tighter chromatin structure and decreased transcription of the USP49 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into DNA, this DNMT inhibitor could decrease methylation levels on the USP49 gene promoter, potentially leading to reduced transcriptional initiation and lower USP49 mRNA levels. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
This compound could directly inhibit DNA methyltransferases, thereby diminishing methylation of the USP49 gene promoter and leading to a decrease in USP49 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
As a nucleoside analog, 5-Aza-2′-Deoxycytidine could substitute for cytosine during DNA replication, leading to a loss of methylation at the USP49 locus and consequent reduction in gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could directly target HDAC enzymes, leading to hyperacetylation of histones associated with the USP49 gene and resulting in decreased transcriptional activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
By selectively inhibiting HDAC enzymes, MS-275 could promote acetylation of histone proteins at the USP49 gene, leading to suppression of its transcription. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
This compound could selectively inhibit HDAC enzymes, reducing deacetylation of histones at the USP49 gene and leading to a decrease in its transcriptional rate. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat could broadly inhibit HDAC activity, potentially leading to a condensed chromatin state at the USP49 promoter and a consequent decrease in USP49 mRNA synthesis. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
By inhibiting HDAC activity, Romidepsin could promote an accumulation of acetylated histones at the USP49 gene, leading to reduced transcriptional elongation of the gene. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $315.00 $1799.00 | ||
This mTOR kinase inhibitor could downregulate the translation of multiple targets, including those that govern the expression of USP49, leading to a reduction in USP49 protein levels. | ||||||