USP49 Activators
USP49 activators primarily include molecules that indirectly influence the activity of USP49 by modulating the intracellular signaling pathways that interact with the ubiquitin-proteasome system. USP49 is a deubiquitinating enzyme, and its activity can be regulated by various cellular processes including the PI3K/Akt pathway, MAPK/ERK pathway, p38 MAPK pathway, JNK pathway, and calcium signaling.
A significant class of USP49 activators includes modulators of the PI3K/Akt pathway, such as Quercetin, LY294002, Genistein, Baicalein, and Triciribine. These molecules can indirectly activate USP49 by either enhancing or inhibiting the PI3K/Akt pathway, which is known to regulate the activity of various ubiquitin-specific proteases. Another class of USP49 activators includes inhibitors of the MAPK/ERK pathway (PD98059), p38 MAPK pathway (SB203580), and JNK pathway (SP600125). The inhibition of these pathways can indirectly activate USP49, as they interact with the ubiquitin-proteasome system, influencing the activity of deubiquitinating enzymes. Molecules that modulate calcium signaling, such as Ionomycin, Thapsigargin, and A23187, also constitute a class of USP49 activators. These molecules indirectly influence the activity of USP49 by altering intracellular calcium levels, which are known to regulate deubiquitinating enzymes. Lastly, a class of USP49 activators includes the Y-27632 molecule, a Rho-associated protein kinase (ROCK) inhibitor. The ROCK pathway is involved in the regulation of various cellular processes, including ubiquitination. Therefore, by inhibiting this pathway, Y-27632 can indirectly activate USP49.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, is known to modulate PI3K/Akt pathway. USP49 being a deubiquitinating enzyme, can be indirectly activated by the upregulation of this pathway, as it has been shown that Akt can modulate the activity of various ubiquitin-specific proteases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. By inhibiting PI3K, it indirectly activates the USP49 enzyme as the inhibition of PI3K leads to the upregulation of Akt, which in turn can modulate the activity of deubiquitinating enzymes like USP49. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MEK inhibitor affecting the MAPK/ERK pathway. The inhibition of this pathway can indirectly result in the activation of USP49, as MAPK/ERK has been implicated in the regulation of ubiquitination processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting the p38 MAPK pathway, it can indirectly activate USP49 as the p38 MAPK pathway has been shown to interact with the ubiquitin-proteasome system. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. By inhibiting the JNK pathway, it can indirectly activate USP49 as the JNK pathway has been shown to interact with the ubiquitin-proteasome system. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, can indirectly activate USP49 due to the involvement of ROCK in the regulation of cellular processes including ubiquitination. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore. Calcium signaling can indirectly activate USP49, as intracellular calcium levels are known to regulate deubiquitinating enzymes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). By inhibiting SERCA, it indirectly activates USP49 by modulating intracellular calcium levels, which regulate deubiquitinating enzymes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion-carrier that forms a stable complex with calcium. By modulating calcium levels, it can indirectly activate USP49 as calcium signaling has been shown to regulate deubiquitinating enzymes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, can indirectly activate USP49 by modulating the PI3K/Akt pathway, as Akt can regulate the activity of various deubiquitinating enzymes. | ||||||