USP26 Activators
USP26 Activators encompass a collection of chemical compounds that facilitate the enhancement of USP26's functional activities through various cellular signaling pathways. Forskolin, by catalyzing an increase in cAMP levels, indirectly augments the activity of USP26 via PKA-mediated phosphorylation, potentially affecting USP26's structural configuration or its interactions with protein substrates. Epigallocatechin gallate and Genistein, both kinase inhibitors, might promote USP26 activity by alleviating competitive signaling pathways, thereby indirectly upregulating the pathways that USP26 is involved in. Similarly, LY294002 and Wortmannin, as PI3K inhibitors, may shift intracellular signaling in favor of USP26 activation by repressing AKT pathway cascades that otherwise suppress USP26's functions.
Likewise, the functional activity of USP26 is supported by manipulations in calcium signaling and MAPK pathway inhibition; Thapsigargin and A23187 both raise intracellular calciumlevels, which could activate calcium-dependent proteins and pathways, subsequently enhancing USP26's activity. PMA, a PKC activator, might indirectly promote USP26's functional state by modulating the phosphorylation status of proteins that interact with USP26. In the context of MAPK signaling, the use of U0126 and SB203580 to inhibit MEK and p38 MAPK, respectively, could allow for the preferential activation of parallel pathways that enhance USP26 activity. Finally, Staurosporine, despite its broad kinase inhibition profile, may selectively release USP26-related pathways from inhibitory control, thereby facilitating the enhancement of USP26-mediated processes..
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylyl cyclase activator, leading to increased cAMP levels. cAMP-dependent protein kinase (PKA) can phosphorylate and thus enhance the activity of various proteins, including USP26, by altering its conformation or interaction with substrates and regulators. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate is a polyphenol that inhibits several protein kinases. By inhibiting competitive signaling pathways, it may enhance signaling pathways that lead to the activation of USP26. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to activate intracellular signaling cascades that can lead to the activation of protein phosphatases, possibly causing dephosphorylation and consequent activation of USP26. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can alter the AKT signaling pathway. This may enhance USP26 activity by shifting the balance of intracellular signaling in favor of pathways that upregulate USP26's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Inhibition of p38 MAPK can lead to the enhancement of alternative signaling pathways that may upregulate the activity of USP26. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). Elevated calcium can activate numerous calcium-dependent proteins and pathways, potentially enhancing the activity of USP26. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins that interact with or regulate USP26, potentially enhancing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may enhance the activity of USP26 by reducing competitive tyrosine kinase signaling, which could indirectly lead to upregulation of USP26's functional pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can alter downstream signaling, potentially enhancing the functional activity of USP26 by modulating the intracellular environment in which USP26 operates. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. These pathways could enhance the activity of USP26 by influencing its state of phosphorylation or conformation. | ||||||