Usherin Inhibitors
Usherin inhibitors belong to a specialized class of chemical compounds designed to target and modulate the activity of the usherin protein within biological systems. Usherin, also known as USH2A, is a large transmembrane protein predominantly found in photoreceptor cells of the retina and certain inner ear cells. It plays a crucial role in maintaining the structural integrity of sensory cilia, which are microtubule-based hair-like structures essential for sensory perception. Usherin inhibitors are engineered to interact with usherin, either by directly binding to it or by interfering with its functional processes, with the aim of regulating specific cellular functions associated with sensory cilia and sensory signal transduction.
The development and study of usherin inhibitors stem from the growing understanding of the importance of usherin in sensory cell biology. Usherin is associated with various inherited sensory disorders, including Usher syndrome, characterized by combined hearing and vision impairment. Usherin inhibitors may offer valuable insights into the mechanisms underlying sensory cilia maintenance and sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates the expression of several genes. Given the role of usherin in the retina, retinoid pathways could potentially influence its expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects multiple cellular pathways. It might interact with signaling pathways that are involved in sensory cell development or maintenance. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, an estrogen receptor modulator, might influence proteins that are responsive to hormonal regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has multiple cellular targets and might interact with pathways that involve sensory cell maintenance. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone can affect a wide range of genes. Its broad effects might include pathways related to sensory cells. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
A PPARα agonist, which might influence genes in lipid metabolism that could be related to cell membrane structures in sensory cells. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
A synthetic retinoid that might influence genes related to retinoid pathways, possibly affecting proteins like usherin. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin might interact with pathways that involve cellular development or maintenance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Might affect cellular pathways related to cell protection or stress response. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
A PPARγ agonist; its effects on lipid metabolism genes could potentially influence usherin indirectly. | ||||||