UGTREL1 Inhibitors
UGTREL1 inhibitors Sulfinpyrazone and Probenecid are known to affect the renal transport of various compounds, which can impact the availability of substrates that UGTREL1 would typically conjugate. This indirect mechanism leads to reduced activity of UGTREL1 due to substrate limitation. On the other hand, compounds such as Quercetin and Piperine have broader effects on cellular enzymes and can alter the phosphorylation state or change the conformation of UGTREL1, respectively. This may lead to a decrease in the enzyme's activity or influence its interaction with substrates.
Similarly, Curcumin and Resveratrol can modulate gene expression and protein stability, which can have downstream effects on UGTREL1's enzymatic function. Compounds like Capsaicin, Epigallocatechin Gallate, and Naringenin can affect UGTREL1 indirectly by altering intracellular signaling cascades or through antioxidant properties that impact oxidative stress-related signaling pathways, which in turn can modulate the function of UGTREL1. Gallotannin and Ellagic Acid are known to chelate with proteins, which can affect the structural integrity and enzymatic activity of UGTREL1. These compounds, through their interaction with the protein, can lead to alterations in the cellular milieu, affecting both the stability and activity of UGTREL1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
Inhibits the uricosuric effect, which can lead to a decrease in the breakdown of substances that UGTREL1 conjugates. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Competes with compound uptake by the same transporters that UGTREL1 substrates use, leading to reduced substrate availability for conjugation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Modulates enzyme activity through its action as a broad-spectrum kinase inhibitor, altering phosphorylation states of proteins, possibly including UGTREL1. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Alters the function of some metabolizing enzymes and could alter UGTREL1 activity by changing its conformation or substrate affinity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Affects multiple signaling pathways and may alter protein function, including that of UGTREL1, by modulating gene expression or protein stability. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Influences metabolic pathways through its interaction with sensory neurons and could indirectly affect UGTREL1 activity by modulating intracellular signaling cascades. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Modulates various signaling pathways and may affect UGTREL1 activity through indirect effects on gene expression and protein stability. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Influences enzyme activities due to its antioxidant properties and may alter the function of UGTREL1 through oxidative stress-related signaling pathways. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Exhibits enzyme modulating properties and may affect UGTREL1 enzyme activity through the alteration of cellular signaling pathways impacting protein function. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Interacts with proteins and enzymes to modulate their activity, and can influence UGTREL1 by altering the cellular milieu, affecting protein stability or enzymatic activity. | ||||||