UBPY Activators
UBPY Activators are a class of chemical compounds that can enhance the functional activity of UBPY, a deubiquitinating enzyme. The functional activity of UBPY is enhanced when the intracellular levels of ubiquitinated proteins are increased. This increase can be achieved by inhibiting autophagy or proteasome pathways, or by inhibiting other DUBs. For instance, autophagy inhibitors such as Chloroquine, 3-Methyladenine, and Bafilomycin A1 work by inhibiting the degradation of ubiquitinated proteins, thereby increasing their concentration and providing UBPY with more substrates to act upon.
Proteasome inhibitors like MG132 and Lactacystin also increase the concentration of ubiquitinated proteins by inhibiting their degradation in the proteasome. Similarly, inhibitors of other DUBs, like Spautin-1 (which inhibits USP10 and USP13), PR-619 (a broad-spectrum DUB inhibitor), and IU1 (a specific USP14 inhibitor), enhance the activity of UBPY by increasing the concentration of ubiquitinated proteins. Eeyarestatin I, an ERAD inhibitor, and Pyr-41, an irreversible ubiquitin-activating enzyme E1 inhibitor, enhance UBPY's activity by increasing the accumulation of ubiquitinated proteins.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can indirectly enhance the functional activity of UBPY by increasing the accumulation of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an autophagy inhibitor that enhances UBPY's activity by increasing the concentration of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is an autophagy inhibitor that enhances UBPY's activity by increasing the concentration of ubiquitinated proteins, which are substrates for UBPY. | ||||||
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | 315706-13-9 | sc-202597 | 10 mg | $265.00 | 14 | |
Eeyarestatin I is an ERAD inhibitor that enhances the functional activity of UBPY by increasing the accumulation of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor that indirectly enhances the functional activity of UBPY by increasing the accumulation of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 is a specific inhibitor of USP10 and USP13, which can indirectly enhance the functional activity of UBPY by increasing the concentration of ubiquitinated proteins, which are substrates for UBPY. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum DUB inhibitor that can indirectly enhance the functional activity of UBPY by increasing the concentration of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is an irreversible ubiquitin-activating enzyme E1 inhibitor, which enhances the functional activity of UBPY by increasing the accumulation of ubiquitinated proteins, which are substrates for UBPY. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is a specific USP14 inhibitor, which can indirectly enhance the functional activity of UBPY by increasing the concentration of ubiquitinated proteins, which are substrates for UBPY. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is an HSP90 inhibitor, which indirectly enhances the functional activity of UBPY by increasing the accumulation of ubiquitinated proteins, which are substrates for UBPY. | ||||||