UBE2C Activators
The chemical class of UBE2C activators consists of compounds that indirectly influence the activity of UBE2C, primarily through their effects on cellular signaling pathways and protein turnover. These activators function by modulating various aspects of cell biology, including the ubiquitin-proteasome system, cell growth, protein synthesis, and degradation pathways. The primary mechanism through which these compounds exert their effects is through the alteration of signaling pathways and protein stability, impacting the ubiquitination process in which UBE2C is a key player.
Compounds such as proteasome inhibitors (e.g., Bortezomib, MG132) and molecular pathway inhibitors (e.g., PI3K inhibitors, mTOR inhibitors) indirectly affect UBE2C by altering the cellular environment. Proteasome inhibitors, for instance, lead to the accumulation of proteins within cells, which can influence the ubiquitin-proteasome system, potentially impacting UBE2C's role in this pathway. Similarly, inhibitors of signaling pathways like PI3K, mTOR, and AKT modulate the balance of protein synthesis and degradation, indirectly affecting UBE2C activity. Other compounds in this class, including HSP90 inhibitors, HDAC inhibitors, and various MAPK inhibitors, influence cell signaling and stress response pathways. By modulating these pathways, these compounds can indirectly affect UBE2C activity. For example, HSP90 inhibitors disrupt protein folding and stability, while HDAC inhibitors alter gene expression and protein acetylation, both of which can impact the ubiquitin-proteasome pathway and UBE2C function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, can indirectly influence UBE2C activity by inhibiting the degradation of proteins, potentially impacting the ubiquitin-proteasome system and indirectly affecting UBE2C activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can indirectly affect UBE2C by inhibiting protein degradation, leading to changes in the ubiquitin-proteasome pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, can affect various signaling pathways, potentially influencing UBE2C activity indirectly through alterations in cell signaling and protein turnover. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can influence cell growth and protein synthesis pathways, potentially affecting UBE2C activity indirectly by altering the balance of protein synthesis and degradation. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206, an AKT inhibitor, can indirectly influence UBE2C by modulating signaling pathways involved in cell survival and protein turnover. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG, an HSP90 inhibitor, can disrupt protein folding and stability, potentially impacting UBE2C activity indirectly through changes in protein turnover and degradation pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, can affect gene expression and protein acetylation, potentially influencing UBE2C activity indirectly through alterations in protein turnover and signaling pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, can influence inflammatory signaling pathways, potentially impacting UBE2C activity indirectly through changes in cellular signaling and protein turnover. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, can modulate stress response pathways, potentially influencing UBE2C activity indirectly through changes in cell signaling and protein turnover. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, can affect stress response and inflammatory signaling, potentially impacting UBE2C activity indirectly through alterations in protein turnover and cellular signaling. | ||||||