TREM-2 Activators
Common TREM-2 Activators include, but are not limited to Rosiglitazone CAS 122320-73-4, Pioglitazone hydrochloride CAS 112529-15-4, Curcumin CAS 458-37-7, Retinoic Acid, all trans CAS 302-79-4 and Simvastatin CAS 79902-63-9.
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a cell surface receptor primarily expressed on microglia, the resident immune cells of the central nervous system (CNS). Microglia play a multifaceted role in the CNS, participating in processes ranging from synaptic pruning during development to mediating inflammatory responses in the face of injury or disease. TREM-2 is instrumental in modulating the functions of microglia. When activated, TREM-2 can influence a range of cellular activities, including phagocytosis, cytokine production, and cell survival. The signaling cascades initiated by TREM-2 activation are complex, involving various adaptor proteins and intracellular pathways. The balance of TREM-2 activity is vital for maintaining homeostasis within the CNS, ensuring that microglia respond appropriately to environmental cues without inadvertently causing harm to neural tissues.
Activators of TREM-2 are molecules or compounds that enhance the expression, stability, or signaling activity of TREM-2. These activators may function by promoting the transcription or translation of the TREM-2 gene, stabilizing the receptor on the cell surface, or augmenting its signaling efficacy upon ligand binding. The presence of TREM-2 activators can modulate microglial behavior, influencing their ability to clear debris, respond to injury, or interact with other cell types in the CNS. Venturing into the world of TREM-2 activators offers a deep dive into the intricate realm of neuroimmunology, shining a light on the delicate molecular interplay that governs immune responses within the brain. As the vast landscape of CNS biology continues to be charted, the role of TREM-2 and its activators stands as a beacon, revealing the nuanced orchestration of immune processes that underpin neural health and function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPARγ agonist that may enhance TREM2 expression in microglial cells, promoting anti-inflammatory responses. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $63.00 $213.00 | 19 | |
Another PPARγ agonist that can potentially upregulate TREM2 expression, aiding in the resolution of inflammation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol that might modulate TREM2 expression through anti-inflammatory pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Might increase TREM2 expression via the retinoic acid receptor (RAR) signaling pathway. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Statin that may increase TREM2 expression, possibly through anti-inflammatory mechanisms. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Has been shown to increase TREM2 expression in microglial cells, potentially aiding in neuroprotection. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
A short-chain fatty acid that might enhance TREM2 expression through its anti-inflammatory properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This polyphenol might modulate TREM2 expression, potentially through sirtuin 1 (SIRT1) activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate that might upregulate TREM2 expression through NRF2-mediated pathways. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Hormone that may increase TREM2 expression in certain conditions, potentially aiding in neuroprotection. | ||||||