TMEM62 Inhibitors
TMEM62 inhibitors belong to a class of chemicals that specifically target the transmembrane protein 62 (TMEM62), which plays a role in various cellular processes. TMEM62, as its name suggests, is embedded within the lipid bilayer of cells, spanning the membrane with multiple domains that interact with the intracellular environment and the extracellular space. The inhibitors designed to affect TMEM62 typically work by binding to the protein and altering its normal function. This interaction can lead to changes in the protein's configuration, preventing it from carrying out its biological role effectively. TMEM62 inhibitors are complex molecules that can be tailored to fit the unique structural features of the protein, engaging with it through a variety of non-covalent interactions such as hydrogen bonding, hydrophobic effects, and van der Waals forces. The precision of these interactions is crucial, as it determines the specificity and efficacy of an inhibitor.
The development of TMEM62 inhibitors requires a deep understanding of the protein's structure and function. The structure of TMEM62 is typically elucidated through techniques like X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy, which provide a high-resolution image of the protein at the atomic level. These images reveal the contours and charge distributions across the protein's surface, which are essential for designing inhibitors that can snugly fit and modulate TMEM62's activity. In terms of function, TMEM62 is implicated in a variety of cellular pathways, and the disruption of its activity by inhibitors can lead to a cascade of effects within the cell. Researchers study these effects using a combination of biochemical assays, cellular studies, and sometimes whole-organism models. By understanding how TMEM62 interacts with other cellular components and how its inhibition alters cellular function, scientists can design more effective inhibitors that are fine-tuned to the protein's unique characteristics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits the mTOR pathway, which is critical for protein synthesis and autophagy. Inhibition of mTOR can downregulate TMEM62, as TMEM62 is thought to be involved in autophagosome formation. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is a PI3K inhibitor that impedes the initiation of autophagy by blocking class III PI3K. Since TMEM62 plays a role in autophagy, its function is indirectly diminished by this compound's action. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 promotes the degradation of PI3K class III complexes, which are essential for the early stages of autophagy. By disrupting these complexes, Spautin-1 indirectly decreases the functional activity of TMEM62. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can block autophagy by inhibiting class I PI3K/Akt pathway. This inhibition may reduce the functional activity of TMEM62 by disrupting the autophagic processes it is implicated in. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that prevents autophagy through inhibition of the PI3K/Akt/mTOR pathway. TMEM62 activity, associated with autophagosome formation, is likely to be suppressed as a result of this inhibition. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine acts by increasing lysosomal pH, which inhibits the fusion between autophagosomes and lysosomes, an essential step in autophagy. This can indirectly inhibit TMEM62 which is involved in autophagosome formation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a V-ATPase inhibitor that prevents lysosomal acidification, thereby blocking autophagosome-lysosome fusion. This action can impede the autophagic function where TMEM62 is implicated. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
SAR405 is a potent and selective inhibitor of Vps34, which is crucial for the initiation of autophagy. By inhibiting Vps34, SAR405 indirectly affects TMEM62's role in autophagy. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
Lys05 is a dimeric chloroquine derivative that inhibits autophagosome-lysosome fusion more potently than chloroquine. This inhibition can indirectly decrease the functional activity of TMEM62. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a potent inhibitor of mTOR, which can suppress autophagy. Given the involvement of TMEM62 in autophagosome formation, Torin 1's action is likely to reduce TMEM62 activity. | ||||||