Molecular structure of Lys05, CAS Number: 1391426-24-6
Lys05 (CAS 1391426-24-6)
Alternate Names:
Lys-01 3HCl, Lys-05, Lys01 3HCl, N-(7-Chloroquinolin-4-yl)-N′-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N′-methylethane-1,2-diamine trihydrochloride, N1-(7-Chloroquinolin-4-yl)-N2-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N2-methylethane-1,2-diamine trihydrochloride, PS-1001, PS1001
CAS Number:
1391426-24-6
Molecular Weight:
549.75
Molecular Formula:
C23H23Cl2N5·3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Lys05 (CAS 1391426-24-6) References
- Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. | McAfee, Q., et al. 2012. Proc Natl Acad Sci U S A. 109: 8253-8. PMID: 22566612
- Lys05: a new lysosomal autophagy inhibitor. | Amaravadi, RK. and Winkler, JD. 2012. Autophagy. 8: 1383-4. PMID: 22878685
- Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. | Baquero, P., et al. 2019. Leukemia. 33: 981-994. PMID: 30185934
- Lys05 induces lysosomal membrane permeabilization and increases radiosensitivity in glioblastoma. | Zhou, W., et al. 2020. J Cell Biochem. 121: 2027-2037. PMID: 31642111
- A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299. | Cechakova, L., et al. 2019. Int J Mol Sci. 20: PMID: 31771188
- Lys05 - A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective. | Ondrej, M., et al. 2020. Cancer Genomics Proteomics. 17: 369-382. PMID: 32576582
- Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer. | Holm, TM., et al. 2022. Surgery. 171: 235-244. PMID: 34565609
- Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms. | Courdy, C., et al. 2023. Blood Cancer J. 13: 106. PMID: 37423955
- Synergistic effect of Dactolisib/Lys05 combination on autophagy in A549 cells. | Abdelwahab, M., et al. 2023. Acta Biochim Pol. 70: 615-622. PMID: 37677845
- Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. | Zhou, X., et al. 2024. Nat Chem Biol. 20: 857-866. PMID: 38355723
Inhibitor of:
5330417C22Rik, 5430411K18Rik, Atg16, Atg16L2, C12orf44, C9orf72, CALCOCO1, CFBP, CLC-7, DPEP2, DRAM2, EG622976, GABARAP, KIAA0146, KIAA0652, LAMP-1, LAPTM4A, MAP LC3β2, NRBF2, RFC-1, Sox-6, SQSTM1, TECPR2, TMEM49, TMEM62, V-ATPase C, vacuolar proton pump, WDR47, and WIPI-4.Activator of:
Aminopeptidase B, AP1S3, BLOS3, C330006K01Rik, MAP LC3α, PLEKHF2, Rab 24, and Rab 26.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lys05, 5 mg | sc-507532 | 5 mg | $140.00 |