Molecular structure of SAR405, CAS Number: 1523406-39-4
SAR405 (CAS 1523406-39-4)
Alternate Names:
(8S)-9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one
CAS Number:
1523406-39-4
Molecular Weight:
443.9
Molecular Formula:
C19H21ClF3N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SAR405 (CAS 1523406-39-4) References
- A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. | Ronan, B., et al. 2014. Nat Chem Biol. 10: 1013-9. PMID: 25326666
- SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. | Pasquier, B. 2015. Autophagy. 11: 725-6. PMID: 25905679
- Research progress of hydroxychloroquine and autophagy inhibitors on cancer. | Shi, TT., et al. 2017. Cancer Chemother Pharmacol. 79: 287-294. PMID: 27889812
- Autophagy inhibition enhances celecoxib-induced apoptosis in osteosarcoma. | Zhou, P., et al. 2018. Cell Cycle. 17: 997-1006. PMID: 29884091
- SAR405, a Highly Specific VPS34 Inhibitor, Disrupts Auditory Fear Memory Consolidation of Mice via Facilitation of Inhibitory Neurotransmission in Basolateral Amygdala. | Li, K., et al. 2019. Biol Psychiatry. 85: 214-225. PMID: 30253884
- Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury. | Quan, X., et al. 2021. Neuroscience. 460: 107-119. PMID: 33600885
- Novel and conventional inhibitors of canonical autophagy differently affect LC3-associated phagocytosis. | Stempels, FC., et al. 2022. FEBS Lett. 596: 491-509. PMID: 35007347
- Hypoxia Induces Autophagy in Human Dendritic Cells: Involvement of Class III PI3K/Vps34. | Monaci, S., et al. 2022. Cells. 11: PMID: 35626732
- Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity. | Sun, X., et al. 2023. Cell Biol Toxicol. 39: 3255-3267. PMID: 37768392
- Short-term autophagy inhibition by autophinib or SAR405 does not alter the effect of cisplatin on ATP production in prostate cancer cells. | Kratochvilova, M., et al. 2024. Bratisl Lek Listy. 124: 84-91. PMID: 38219060
Inhibitor of:
13orf18_5031414D18Rik, 5330417C22Rik, 5430411K18Rik, APG7, AQR, Atg10, Atg12, Atg13, Atg16L2, Atg2A, Atg2B, Atg3, Atg4D, Atg9b, C11orf74, CALCOCO1, CHMP4B, D030074E01Rik, DRAM2, FYCO1, GABARAP, KIAA0146, KIAA0226, KIAA0652, MAP LC3α, MAP LC3β, MAP LC3β2, MTMR15, nephrin, NRBF2, PIPK II γ, PLEKHF1, PLEKHM2, Rab L5, Ribosomal Protein L13A, SIAH-1, SNX8, Syntaxin 17, TBC1D5, TECPR1, TMEM41A, TMEM49, TMEM62, TRIM16, UVRAG, VAC14, Vacuolar Protein Sorting (VPS), Vps34, WDFY2, WDFY4, WDR47, WIPI-1, WIPI-2, WIPI-4, YIPF4, ZFYVE1, and ZKSCAN3.Activator of:
Atg4C, IRGM, and MVB12A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAR405, 1 mg | sc-507416 | 1 mg | $125.00 |