TMEM156 Activators
TMEM156 activators represent a diverse set of chemicals that intricately modulate the activation state of TMEM156, a protein with emerging significance in cellular processes. While direct activators specific to TMEM156 remain elusive, the selected compounds exert their influence through indirect mechanisms, reflecting the intricate web of signaling pathways interwoven with TMEM156 function. One notable activator, A23187, operates by elevating intracellular calcium levels, influencing TMEM156 through calcium-dependent signaling pathways. Similarly, Thapsigargin induces endoplasmic reticulum stress, activating the unfolded protein response (UPR), and indirectly impacting TMEM156, which is closely linked to UPR pathways. Additionally, SB203580, indirectly affects TMEM156 activation by modulating the p38 signaling pathway, demonstrating the intricate cross-talk between TMEM156 and MAPK pathways.
Epigenetic modulators like Trichostatin A and Resveratrol showcase the dynamic relationship between TMEM156 and chromatin landscape. These compounds alter histone acetylation patterns, indirectly influencing TMEM156 through epigenetic regulation and subsequent changes in gene expression. Compounds such as Niclosamide and Rapamycin highlight the interconnectedness of cellular energy sensing pathways with TMEM156. Niclosamide disrupts mitochondrial function, leading to AMPK activation, while Rapamycin inhibits mTOR, indirectly affecting TMEM156 through its association with mTOR pathways. The TMEM156 activators collectively emphasize the complexity of cellular regulation and the multifaceted nature of TMEM156-associated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that elevates intracellular calcium levels. Indirectly activates TMEM156 by modulating calcium-dependent signaling pathways, potentially influencing TMEM156 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, dampening the p38 signaling pathway. Indirectly affects TMEM156 activation, given its association with p38 MAPK signaling in certain cellular contexts. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide disrupts mitochondrial function, leading to AMPK activation. AMPK modulation indirectly activates TMEM156, as AMPK and TMEM156 are interconnected in cellular energy sensing pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, modifies histone acetylation patterns. This epigenetic modulation indirectly activates TMEM156 by influencing the chromatin landscape and subsequent gene expression changes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a NAD+-dependent deacetylase. SIRT1 influences TMEM156 indirectly through deacetylation of proteins involved in cellular processes, contributing to TMEM156 activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER stress by inhibiting SERCA, leading to UPR activation. The UPR indirectly influences TMEM156 activation, as TMEM156 is linked to ER stress responses and its activity is modulated in these conditions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, affecting downstream signaling. This indirect modulation activates TMEM156, given its connection to mTOR pathways in cellular growth and survival regulation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is an AMPK activator, influencing cellular energy homeostasis. Indirectly activates TMEM156 by engaging AMPK-dependent pathways and cross-talk, regulating TMEM156 activity in response to cellular energy status. | ||||||
PTP CD45 Inhibitor | 345630-40-2 | sc-222223A sc-222223 | 1 mg 5 mg | $102.00 $300.00 | 1 | |
SF1670 inhibits PIM1 kinase, disrupting PIM1 signaling pathways. Indirectly activates TMEM156 by perturbing the balance within PIM1-mediated cellular processes, influencing TMEM156 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, altering DNA methylation patterns. This epigenetic change indirectly activates TMEM156 by modulating the transcriptional regulation of genes associated with TMEM156 function. | ||||||