TMEM12 Activators
TMEM12 has its activity enhanced through the modulation of various cellular signaling pathways and ion dynamics. The selective inhibition of epithelial sodium channels by certain compounds causes an intracellular accumulation of sodium ions, which then modulate sodium-sensitive pathways directly linked to TMEM12, resulting in its increased activity. Other molecules stimulate adenylate cyclase, leading to an elevation of cAMP within cells. This surge in cAMP activates protein kinase A, which can phosphorylate several targets that interact with TMEM12, indirectly enhancing its function. Additionally, analogs resembling diacylglycerol activate protein kinase C, which phosphorylates proteins that regulate or interact with TMEM12, thus potentiating its role within the cell.
Further involvement of TMEM12 in the regulation of cellular processes is seen when ion dynamics are manipulated. Calcium ionophores raise intracellular calcium levels, activating calcium-dependent proteins that may interact with TMEM12, thereby increasing its activity. Conversely, calcium chelators initiate a cellular adaptation process that may involve the activation of TMEM12 to restore calcium homeostasis. Inhibitors of tyrosine kinases and ADP-ribosylation factors indirectly increase TMEM12 activity by modulating downstream signaling cascades or by compensating for disrupted organelle structure and vesicle trafficking. Additionally, the alteration of phosphorylation states, either by inhibiting protein phosphatases or by blocking specific ion channels, results in a change in the activity of various proteins, including those that may be involved in the trafficking, localization, or regulation of TMEM12. For instance, if a phosphatase that normally dephosphorylates a protein interacting with TMEM12 is inhibited, the persistent phosphorylation of that protein could lead to a functional upregulation of TMEM12.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamil•HCl | 161804-20-2 | sc-201070 | 50 mg | $195.00 | 1 | |
An amiloride analog that selectively inhibits epithelial sodium channels (ENaC). Inhibiting ENaC leads to a build-up of sodium ions within the cell, which in turn can modulate the sodium-sensitive pathways that TMEM12 is involved in, enhancing its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase which increases cAMP levels within cells. Elevated cAMP can activate protein kinase A (PKA), and PKA can phosphorylate various targets that might interact with TMEM12, thus increasing TMEM12 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diacylglycerol (DAG) analog that activates protein kinase C (PKC). Activation of PKC can lead to the phosphorylation of proteins that interact with or regulate TMEM12, thereby enhancing its function. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cell-permeable cAMP analog which activates PKA. Activation of PKA can lead to phosphorylation and modulation of various proteins that may interact with TMEM12, facilitating its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent proteins which may interact with TMEM12, leading to increased activity of TMEM12. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A cell-permeable calcium chelator that, once inside the cell, binds calcium and prevents its effects. The subsequent adaptation of the cell to restore calcium levels can involve TMEM12 activation to regulate ion homeostasis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor which can indirectly increase TMEM12 activity by modulating downstream signaling cascades that involve tyrosine phosphorylation, potentially affecting TMEM12 interactions and activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), which disrupts organelle structure and vesicle trafficking. By affecting these processes, the cellular machinery may compensate by upregulating TMEM12 activity to maintain cellular function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
An inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This heightened phosphorylation state can enhance TMEM12 activity through altered protein-protein interactions. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
An L-type calcium channel blocker that, by inhibiting calcium influx, may lead to compensatory cellular responses that include the activation of proteins such as TMEM12 to maintain calcium homeostasis. | ||||||