Molecular structure of Benzamil•HCl, CAS Number: 161804-20-2
Benzamil•HCl (CAS 161804-20-2)
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Alternate Names:
Benzamil hydrochloride; N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide . HCl
Application:
Benzamil•HCl is a potent blocker of sodium channels and Ca2+ transients
CAS Number:
161804-20-2
Molecular Weight:
356.21
Molecular Formula:
C13H14ClN7O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Benzamil•HCl is a potent sodium channel blocker. Benzamil•HCl has been shown to be capable of blocking Ca2+ transients in cardiomyocytes. It has been observed to produce a strong depressive effect on peak developed tension and tension generation and dissipation rates upon addition to the coronary perfusate of the right ventricular wall. Benzamil•HCl is reported to decrease ACE, renin, and ANG II type 1 receptor mRNAs in DOCA-salt hypertensive rats upon intracerebroventricular infusion.
Benzamil•HCl (CAS 161804-20-2) References
- Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels. | Nishimura, M., et al. 1999. Am J Physiol. 276: R1416-24. PMID: 10233035
- In vitro antimicrobial activity of amiloride analogs against Pseudomonas. | Cohn, RC., et al. 1992. Chemotherapy. 38: 232-7. PMID: 1473362
- Pathological circumstances impair the ability of 'dark' neurons to undergo spontaneous recovery. | Gallyas, F., et al. 2006. Brain Res. 1110: 211-20. PMID: 16872583
- Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. | Priori, SG. and Corr, PB. 1990. Am J Physiol. 258: H1796-805. PMID: 2163219
- Sodium Glucose Cotransporter 2 (SGLT2) Plays as a Physiological Glucose Sensor and Regulates Cellular Contractility in Rat Mesangial Cells. | Wakisaka, M., et al. 2016. PLoS One. 11: e0151585. PMID: 26999015
- Analysis of the rat chorda tympani nerve response to 'super salty' sodium carbonate. | Breza, JM. and St John, SJ. 2023. Chem Senses. 48: PMID: 37224503
- Effect of central infusion of benzamil on Dahl S rat hypertension. | Gomez-Sanchez, EP. and Gomez-Sanchez, CE. 1995. Am J Physiol. 269: H1044-7. PMID: 7573500
- Effect of central amiloride infusion on mineralocorticoid hypertension. | Gomez-Sanchez, EP. and Gomez-Sanchez, CE. 1994. Am J Physiol. 267: E754-8. PMID: 7977727
- Modulation of cardiac performance by amiloride and several selected derivatives of amiloride. | Pierce, GN., et al. 1993. J Pharmacol Exp Ther. 265: 1280-91. PMID: 8510009
- Temperature and amiloride alter taste nerve responses to Na+, K+, and NH+4 salts in rats. | Lundy, RF. and Contreras, RJ. 1997. Brain Res. 744: 309-17. PMID: 9027390
- Exacerbation of acetazolamide teratogenesis by amiloride and its analogs active against Na+/H+ exchangers and Na+ channels. | Bell, SM., et al. 1997. Reprod Toxicol. 11: 823-31. PMID: 9407593
Inhibitor of:
γENaC, 6330403A02Rik, AE4, ASIC-β, ASIC2, ASIC3, CLC-K1, CLC-KA, CLC-KB, CLCA5_Clac5, cyclin M1, ESPNL, GPR89, GPR89B, MIP-T3, Na+ CP type IIα, Na+ CP type III, Na+ CP type VIIα, Na+ CP type XIα, NHE-3, NHE-6, NKCC1, OTOP2, SLC24A1, SLC38A6, sNHE, SVOP, TMEM120B, TMTC3, and TREK-2.Activator of:
ELFN1, OTOP2, SLC26A8, and TMEM12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzamil•HCl, 50 mg | sc-201070 | 50 mg | $195.00 |