THAP6 Inhibitors
THAP6 inhibitors belong to a class of compounds designed to selectively interfere with the function of the THAP6 protein. THAP, or Thanatos-associated protein domain, is a type of zinc-dependent DNA-binding domain that is found in a family of proteins implicated in various cellular processes including proliferation, differentiation, and apoptosis. The THAP6 protein, a member of this family, has a specific role in cellular function through its interaction with other proteins and DNA sequences. The inhibitors targeting THAP6 are crafted to bind to this protein and modulate its activity. The design of such inhibitors is typically based on the understanding of the protein's structure and the key interactions that are crucial for its function. These interactions involve the recognition and binding of specific DNA sequences or the formation of complexes with other proteins, which in turn are essential for the proper execution of cellular events.
The development of THAP6 inhibitors involves a sophisticated approach that includes structure-activity relationship (SAR) studies to optimize their binding affinity and selectivity. By altering the chemical structure of these compounds, scientists aim to improve their ability to interfere with the THAP6 protein while minimizing effects on other proteins. The chemical structures of THAP6 inhibitors often contain a central core that interacts with the zinc ion present in the THAP domain, which is crucial for the DNA-binding ability of the protein. Surrounding this core are various chemical groups that are designed to fit into the specific contours of the THAP6 protein's binding site, ensuring a strong and specific interaction. These molecular features are critical for the function of the inhibitors, as they determine the compound's specificity and its overall ability to modulate the activity of the THAP6 protein without affecting other THAP family members or unrelated proteins with similar domains.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises endosomal pH which can disrupt the endosomal sorting complexes required for transport (ESCRT) machinery, relevant for the trafficking of various cellular proteins. THAP6 is a nuclear protein that may be indirectly impacted by alterations in intracellular trafficking and localization due to chloroquine's actions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially causing an accumulation of proteins that could interfere with the normal function of THAP6 by disrupting protein turnover mechanisms THAP6 relies on for functional regulation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus structure and function, which could indirectly affect the post-translational modification of proteins such as THAP6, leading to its functional inhibition by altering its processing or trafficking within the cell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which could affect the ERK pathway. Since THAP6 may interact with components of signal transduction pathways, inhibiting MEK could lead to a decrease in THAP6 activity if THAP6 is involved in such pathway cross-talk. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, disrupting the PI3K/Akt pathway, which is crucial for multiple cellular processes. Inhibiting this pathway could lead to indirect inhibition of THAP6 if THAP6 is associated with cellular growth signals regulated by PI3K/Akt. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which is involved in the response to stress and inflammation. Inhibition of p38 could affect THAP6 function if THAP6 is indirectly modulated by stress-responsive signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, like LY294002, and it would have similar effects on THAP6 if THAP6 is involved in signaling pathways regulated by PI3K/Akt. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which affects chromatin structure and gene expression. As THAP6 is a nuclear protein potentially associated with transcription regulation, Trichostatin A could indirectly inhibit the function of THAP6 by altering the transcriptional landscape within the cell. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, thereby affecting the NFAT signaling pathway. If THAP6 is part of or affected by this pathway, its function could be indirectly inhibited by Cyclosporin A. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase, disrupting cellular ATP levels. As a nuclear protein, THAP6 could require ATP-dependent processes for its function, and oligomycin could therefore indirectly inhibit THAP6 function by limiting available ATP. | ||||||