TGIF inhibitors belong to a class of small molecules or compounds that have garnered significant attention in the field of molecular biology and cellular signaling pathways. TGIF, which stands for Transforming Growth Factor-beta-induced factor, is a transcriptional corepressor protein that plays a crucial role in modulating gene expression. It is a member of the TGIF family of proteins, which are known to interact with various transcription factors and co-regulators to regulate the transcription of target genes. TGIF itself is involved in multiple cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Researchers have identified TGIF inhibitors as compounds capable of disrupting the interaction between TGIF and its binding partners, thereby affecting downstream gene expression.
The mechanism of action of TGIF inhibitors primarily involves their ability to interfere with the binding of TGIF to its target proteins, such as specific transcription factors and co-regulators. By disrupting these protein-protein interactions, TGIF inhibitors can alter the transcriptional activity of genes under the control of TGIF, ultimately influencing cellular processes. This class of inhibitors has shown promise as valuable tools for studying the molecular mechanisms underlying gene regulation and cellular signaling pathways. Researchers have used TGIF inhibitors to investigate the role of TGIF in various biological contexts, shedding light on its importance in development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
This compound potentially inhibits the Hedgehog signaling pathway, which may indirectly lead to the downregulation of TGIF expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting mTOR pathway, rapamycin could potentially lead to altered transcriptional regulation, thereby affecting TGIF expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY 294002 may alter downstream signaling pathways and potentially result in reduced TGIF expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor can potentially modulate chromatin structure and affect the transcription of genes, including TGIF. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
By inhibiting DNA methylation, this compound may lead to the reactivation of silenced genes and potential reduction in TGIF expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
As a flavonoid with antioxidant properties, quercetin may potentially modulate various signaling pathways and influence TGIF expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known for its anti-inflammatory properties, curcumin may potentially affect the transcriptional regulation of various genes, including TGIF. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This compound is thought to have anti-aging and antioxidant properties, which could potentially influence TGIF expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may potentially modulate various cellular pathways and affect TGIF expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone, genistein may influence estrogen signaling and potentially lead to altered TGIF expression. | ||||||