TFIIH p52 Activators
TFIIH p52 activators are a suite of chemical compounds that facilitate the enhancement of TFIIH p52, a subunit of the general transcription and DNA repair factor TFIIH, through indirect yet specific pathways. Caffeine, for instance, raises the levels of cAMP, which activates protein kinase A (PKA) and could enhance the phosphorylation status of transcription-related factors, indirectly aiding TFIIH p52's role in transcription initiation. Resveratrol, via SIRT1 activation, potentially improves chromatin accessibility, thus favoring TFIIH p52's involvement in transcription. Menadione's induction of oxidative stress can heighten TFIIH p52's DNA repair response, while trichostatin A and 5-Azacytidine modify the epigenetic landscape, potentially increasing TFIIH p52's access to DNA. Curcumin and epigallocatechin gallate's modulation of transcription factor activity might lead to a similar increase in TFIIH p52's transcriptional engagements.
In the realm of metabolic regulation, compounds like AICAR and pioglitazone impact energy-sensing pathways and nuclear receptor signaling, respectively, with probable upshots on TFIIH p52's transcriptional activity. Betulinic acid, by stimulating MAPK pathways, and sulforaphane, through Nrf2 pathway activation, could indirectly enhance TFIIH p52's role in transcriptional regulation. Lastly, olaparib, by inhibiting PARP enzymes and thereby allowing the accumulation of DNA damage, could necessitate an increased activity of TFIIH p52 in DNA repair pathways. These activators, while diverse in their primary mechanisms of action, converge on the upregulation of TFIIH p52's functional activities within the cell, highlighting the intricate web of signaling pathways that TFIIH p52 is interwoven with.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate components of the transcription machinery, potentially enhancing the activity of TFIIH p52 in transcription initiation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase that modifies chromatin structure and transcription factors. Through its action on SIRT1, resveratrol can lead to an environment that facilitates the transcriptional activity involving TFIIH p52. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDAC). By preventing deacetylation, it maintains a more open chromatin structure, which can enhance the accessibility of TFIIH p52 to DNA, thereby promoting its role in DNA repair and transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By reducing DNA methylation, it can enhance the binding accessibility of transcription complexes including TFIIH p52 to promoter regions, thus enhancing transcription initiation. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Menadione induces oxidative stress, which can lead to the activation of transcription factors and stress response elements. This stress response can include the enhanced activity of proteins like TFIIH p52 in repairing DNA damage. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which may reduce the transcriptional demand on the cell and indirectly enhance the availability of TFIIH p52 for other transcriptional activities. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate inhibits DNA methyltransferases, leading to hypomethylation of DNA and potentially increased transcription factor binding. This can enhance the functional activity of TFIIH p52 by improving its access to DNA. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone activates PPARγ, which can interact with other transcription factors and cofactors, potentially enhancing the recruitment and activity of TFIIH p52 in transcription complexes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can modulate transcriptional activity by phosphorylating transcription factors and coactivators. This may indirectly increase the functional activity of TFIIH p52 by modulating the transcriptional machinery. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid activates MAPK pathways that can lead to the phosphorylation of transcription factors, potentially enhancing the recruitment and activity of TFIIH p52 in transcription initiation. | ||||||