Tect1 Activators
Tect1 function through various signaling pathways to modulate its activity by altering the intracellular levels of cyclic AMP (cAMP), which in turn activates Protein Kinase A (PKA), the enzyme responsible for phosphorylating and activating Tect1. Forskolin directly stimulates adenylyl cyclase, the enzyme that converts ATP to cAMP, thus leading to an increase in cAMP levels. Similarly, Isoproterenol, a beta-adrenergic agonist, and compounds like Epinephrine and Terbutaline bind to beta-adrenergic receptors, which signal through Gs proteins to activate adenylyl cyclase. The increased cAMP production from adenylyl cyclase activation initiates a cascade of events that leads to the activation of PKA, which subsequently phosphorylates Tect1, altering its activity.
IBMX and Rolipram work by inhibiting phosphodiesterases, the enzymes responsible for cAMP degradation, thereby increasing cAMP levels indirectly. This inhibition results in sustained activation of PKA and prolonged phosphorylation of Tect1. Dopamine and Adenosine, through their interactions with specific G protein-coupled receptors (GPCRs), also activate adenylyl cyclase, thus raising cAMP levels and leading to PKA-mediated phosphorylation of Tect1. Histamine takes a similar route by engaging H2 receptors that signal through the Gs protein to adenylyl cyclase. Anagrelide inhibits phosphodiesterase III, which results in increased cAMP within cells, further contributing to the activation of PKA and subsequent phosphorylation of Tect1. Salbutamol, like other beta-adrenergic agonists, also leads to the activation of PKA through Gs protein-mediated stimulation of adenylyl cyclase, which facilitates the activation of Tect1. Each of these chemicals, through their unique interactions with cellular signaling mechanisms, ultimately converge on the pathway leading to the activation of Tect1 via phosphorylation by PKA.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors, which signal through Gs proteins to activate adenylyl cyclase, increasing cAMP levels, subsequently activating PKA, which can then activate Tect1 by phosphorylation within the cAMP signaling cascade. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
PGE1 activates G protein-coupled receptors (GPCRs) that signal through Gs proteins to stimulate adenylyl cyclase, raising intracellular cAMP levels and activating PKA. PKA then phosphorylates target proteins, including Tect1, leading to its functional activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly increases cAMP levels, leading to the activation of PKA, which can phosphorylate and activate Tect1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine engages beta-adrenergic receptors, triggering a Gs protein-mediated increase in adenylyl cyclase activity, leading to a rise in cAMP and activation of PKA. PKA then has the capacity to phosphorylate and activate Tect1 within the adrenergic signaling pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can interact with dopamine receptors that signal through Gs proteins to stimulate adenylyl cyclase, increasing cAMP and thereby activating PKA, which potentially phosphorylates and activates Tect1 within dopaminergic signaling pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H2 receptors, activates adenylyl cyclase via Gs proteins, leading to increased cAMP levels and activation of PKA. PKA can then activate Tect1 by phosphorylation in the histamine signaling pathway. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine acts on A2A and A2B receptors, which are coupled to Gs proteins, resulting in the activation of adenylyl cyclase, increased cAMP levels, and subsequent activation of PKA. PKA can then phosphorylate and activate Tect1 as part of purinergic signaling. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that activates beta2-adrenergic receptors linked to Gs proteins, stimulating adenylyl cyclase, increasing cAMP, and activating PKA, which may phosphorylate and activate Tect1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels, which activates PKA. Activated PKA is known to phosphorylate various proteins, which could include Tect1 in the cAMP-dependent signaling pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol, a selective beta2-adrenergic agonist, binds to beta2-adrenergic receptors, activating Gs proteins, which in turn activate adenylyl cyclase. The resulting increase in cAMP levels leads to the activation of PKA, which could phosphorylate and activate Tect1 within the adrenergic signaling pathway. | ||||||