Tect1 Inhibitors
Tect1 inhibitors are a class of chemical compounds designed to selectively inhibit the activity of Tect1, a protein that plays a critical role in the structural organization of specialized cellular environments, such as the extracellular matrix (ECM) and synaptic regions. Tect1, also known as Tectorin Alpha, is primarily involved in the formation of the tectorial membrane, a structure in the inner ear essential for sound wave transmission to sensory cells. By interacting with extracellular matrix proteins, Tect1 helps maintain the integrity of the tectorial membrane and contributes to the proper functioning of auditory mechanisms. Inhibitors targeting Tect1 disrupt its interaction with other structural proteins, potentially affecting the assembly or maintenance of ECM-related structures and altering the mechanical properties of these regions.
Tect1 inhibitors serve as important tools in research focused on understanding the molecular basis of protein interactions within the extracellular matrix and their broader role in cellular architecture. By inhibiting Tect1, researchers can study how disruptions in the structural components of specific tissues, like the inner ear, affect overall cellular communication and mechanical stability. These inhibitors also provide a way to investigate how changes in the structural properties of the extracellular matrix impact processes such as cell adhesion, tissue development, and signal transmission. By blocking Tect1's function, scientists can gain insights into the dynamic interactions between matrix proteins and their role in maintaining the physical and functional integrity of specialized biological structures. Tect1 inhibitors, therefore, represent a key tool for probing the detailed mechanisms of extracellular matrix composition and how it contributes to the overall architecture of complex tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
A steroidal alkaloid that antagonizes the Hedgehog (Hh) signaling pathway by binding to and inhibiting the Smoothened (Smo) receptor. Tect1 is implicated in the ciliogenesis and the Hh pathway; inhibition of Smo with cyclopamine can lead to reduced activity of Tect1 due to downstream effects on ciliary function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase which increases cAMP levels, leading to activation of PKA. Elevated PKA activity can inhibit the Hh pathway, which interacts with Tect1 function in ciliary processes; thus, forskolin can indirectly decrease Tect1 activity. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
This compound targets the Hh signaling pathway by binding to Smo, which is essential for pathway activation. Since Tect1 is associated with ciliary processes and the Hh pathway, vismodegib indirectly reduces Tect1 functional activity. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
A naturally occurring steroidal alkaloid that inhibits the Hh signaling pathway by directly interacting with Smo. The inhibition of Smo leads to reduced activity of downstream components, which includes Tect1-associated ciliary mechanisms. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
An inhibitor that targets the Gli transcription factors of the Hh pathway. By preventing Gli-mediated transcription, GANT61 indirectly lessens Tect1 activity due to its reliance on Hh pathway-mediated ciliogenesis. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
A cholesterol transport inhibitor that disrupts intracellular cholesterol homeostasis, affecting the localization and function of Smo within the Hh pathway. Tect1, being involved in ciliary function and Hh signaling, is indirectly inhibited by U18666A. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
A potent antagonist of Smo, SANT-1 specifically inhibits Hh pathway signaling. As Tect1 function is linked to ciliary processes governed in part by the Hh pathway, SANT-1 can result in diminished Tect1 activity. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
An antifungal agent that, besides its primary action, has been found to inhibit the Hh signaling pathway by preventing Smo accumulation in the primary cilia. Reduced Hh signaling can lead to decreased Tect1 function related to ciliogenesis. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-β type I receptor ALK5, which has been shown to be involved in ciliary length and function. Tect1, a protein associated with ciliary processes, may have its activity indirectly inhibited due to altered ciliary dynamics induced by SB-431542. | ||||||