Molecular structure of GANT61, CAS Number: 500579-04-4
GANT61 (CAS 500579-04-4)
See product citations (6)
Alternate Names:
2,2′-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Application:
GANT61 is an antiproliferative Hh signaling pathway inhibitor
CAS Number:
500579-04-4
Purity:
>95%
Molecular Weight:
429.60
Molecular Formula:
C27H35N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GANT61 is a cell-permeable hexahydropyrimidine compound, shown to be an inhibitor of GLI-mediated gene transactivation. GLI-mediated transcription is the final step in the Hedgehog (Hh) signaling pathway, therefore GANT61 halts hedgehog pathway effects. Sonic hedgehog, a homolog of Hedgehog is essential for proper embryonic development and the interference of GANT61 with its production could lead to potential developmental issues. Additionally, this compound was found to successfully inhibit proliferation of tumor cells in vitro in a GLI-dependent manner. GANT61 is an inhibitor of GLI-1 and GLI-2.
GANT61 (CAS 500579-04-4) References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. | Lauth, M., et al. 2007. Proc Natl Acad Sci U S A. 104: 8455-60. PMID: 17494766
- Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells. | Guan, CC., et al. 2009. Bone. 45: 1146-52. PMID: 19683085
- Small-molecule modulators of the Sonic Hedgehog signaling pathway. | Stanton, BZ. and Peng, LF. 2010. Mol Biosyst. 6: 44-54. PMID: 20024066
- GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment. | Li, J., et al. 2016. J Exp Clin Cancer Res. 35: 184. PMID: 27894350
- Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells. | Li, J., et al. 2017. Biochem Biophys Res Commun. 493: 487-493. PMID: 28870808
- Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway. | Niu, C., et al. 2019. Autophagy. 15: 843-870. PMID: 30653446
- Gant61 ameliorates CCl4-induced liver fibrosis by inhibition of Hedgehog signaling activity. | Jiayuan, S., et al. 2020. Toxicol Appl Pharmacol. 387: 114853. PMID: 31816328
- GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway. | Zhang, Z., et al. 2020. Med Sci Monit. 26: e920541. PMID: 32054823
- A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent manner through inhibiting Notch pathway in multiple myeloma. | Zhang, Z., et al. 2020. Cell Cycle. 19: 2063-2073. PMID: 32677544
- GANT61 elevates chemosensitivity to cisplatin through regulating the Hedgehog, AMPK and cAMP pathways in ovarian cancer. | Zhu, P., et al. 2022. Future Med Chem. 14: 479-500. PMID: 35322690
- GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma. | Gao, H., et al. 2022. Cancer Biol Ther. 23: 369-377. PMID: 35491899
- GANT61/BI-847325 combination: a new hope in lung cancer treatment. | El-Kishky, AHM., et al. 2022. Med Oncol. 39: 144. PMID: 35834029
- GANT61 exerts anticancer cell and anticancer stem cell capacity in colorectal cancer by blocking the Wnt/β‑catenin and Notch signalling pathways. | Si, Y., et al. 2022. Oncol Rep. 48: PMID: 36069229
Inhibitor of:
ΔN p63, APCDD1L, ASCL1, BY080835, C2CD3, DAND5, DAZ Interacting Zinc Finger Proteins (DZIP), DCHS2, DISP1, DISP2, Dlx-2, EG229879, Gas1, GBX2, GLI-1, GLI-2, GLIPR1L3, HATH-1, HDRP, hedgehog, HH, HHAT, Hhip, HHIPL1, HHIPL2, HoxB5, IFT80, INTU, KCTD7, KIAA0586, KIAA1822L, Lamin B receptor, LELP1, LMBR1, LMBR1L, LOC257407, LOC388963, MACS1, MAMLD1, MESP2, NG2, NK homeobox (NKX), Nkx-2.2, Nkx-3.2, Olfr49, Olfr490, patched 2, PTCHD1, PTCHD2, PTCHD3, Scratch1, Shh, Su(fu), Syndecan-4, Tect1, TMEM218, TMEM231, TTC21B, TULP3, USP28, V1RG12, VAX1, WDR11, Zic1, and Zic5.Activator of:
achaete, cubitus interruptus, DISP2, DZIP1, EVC2, GLI-1, hedgehog, HH, Hip, KIAA1822L, KIF7, LRF, PTCHD1, PTCHD4, and Smo.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GANT61, 1 mg | sc-202630 | 1 mg | $63.00 | |||
GANT61, 5 mg | sc-202630A | 5 mg | $128.00 | |||
GANT61, 10 mg | sc-202630B | 10 mg | $200.00 |