Molecular structure of U 18666A, CAS Number: 3039-71-2
U 18666A (CAS 3039-71-2)
See product citations (2)
Alternate Names:
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Application:
U 18666A is a cell-permeable amphiphilic amino-steroid
CAS Number:
3039-71-2
Purity:
>95%
Molecular Weight:
424.06
Molecular Formula:
C25H41NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U 18666A is a cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol, presumably via its inhibitory effect on 2,3-oxidosqualene-lanosterol cyclase activity. It is also a weak inhibitor of hedgehog (Hh) signaling. U 18666A is a compound derived from the androgenic hormone testosterone, and its application in laboratory research has been to explore the impacts of androgens on the body.
U 18666A (CAS 3039-71-2) References
- Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. | Rocha, N., et al. 2009. J Cell Biol. 185: 1209-25. PMID: 19564404
- Simvastatin induced neurite outgrowth unveils role of cell surface cholesterol and acetyl CoA carboxylase in SH-SY5Y cells. | Raina, V., et al. 2013. PLoS One. 8: e74547. PMID: 24040277
- The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA. | Wang, H., et al. 2016. Mol Ther. 24: 2100-2108. PMID: 27633442
- Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells. | Morel, E., et al. 2018. Biochim Biophys Acta Mol Cell Biol Lipids. 1863: 199-211. PMID: 29196159
- Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in bunyavirus entry. | Charlton, FW., et al. 2019. J Biol Chem. 294: 7335-7347. PMID: 30804209
- Identification of a novel splice site mutation in the SERAC1 gene responsible for the MEGDHEL syndrome. | Snanoudj, S., et al. 2019. Mol Genet Genomic Med. 7: e815. PMID: 31251474
- Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. | Snodgrass, RG., et al. 2021. Cell Death Differ. 28: 1301-1316. PMID: 33177619
- NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. | Davis, OB., et al. 2021. Dev Cell. 56: 260-276.e7. PMID: 33308480
- Influence of fluorophore and linker length on the localization and trafficking of fluorescent sterol probes. | Králová, J., et al. 2020. Sci Rep. 10: 22053. PMID: 33328481
- In Vitro Confirmation of Siramesine as a Novel Antifungal Agent with In Silico Lead Proposals of Structurally Related Antifungals. | Vlainić, J., et al. 2021. Molecules. 26: PMID: 34201401
- Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. | Malhi, M., et al. 2021. Commun Biol. 4: 1239. PMID: 34716403
- A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. | Tanton, H., et al. 2022. Sci Adv. 8: eabm3108. PMID: 35486727
- Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. | Kanemaru, K., et al. 2022. Nat Commun. 13: 2347. PMID: 35534464
- Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling. | Bridgeman, S., et al. 2022. Int J Mol Sci. 23: PMID: 36555149
Inhibitor of:
2810008M24Rik, 4930485B16Rik, 4932438H23Rik, 5430405G05Rik, ACBD5, apoF, ATP9A, BLOS2, cathepsin D, CCDC132, CCDC43, CCDC55, CCZ1, CD1D, CD1E, CFBP, CHMP4B, CHMP7, CLCC1, DHCR7, ENSMUSG00000056133, FCHO1, FMVB12B, GAAP, GLIPR1L1, GM2-AP, Gm438, Gm581, Gm889, GML, GPAA1, hedgehog, HHAT, HPS-6, Hrs, IDI1, IFITM5, IFT80, LAMP-5, LAPTM5, LDLRAD4, LELP1, LIMP II, LIMP III, LMBRD1, LRP11, MKS3, mucolipin 1, MVB12A, N-myristoyltransferase 2, NAALADL1, NR5A2, ORP-7_Osbpl7, PLEKHM2, PPT2, PRP2, PTAG, RAb 19B, Rabex-5, Rae-1β, RHBDD2, SEC14L1, Sec15A, SERINC1, SERINC4, SID-1, SLMO2, SNX33, SNX8, SPATA5, SPPL2b, StARD6, sulfamidase, SUSD3, Tect1, TLR13, TM4SF4, TM6SF1, TM9SF1, TMED6, TMEM106B, TMEM168, TMEM177, Tmem210, TMEM231, TMEM29, TMEM39A, TMEM41B, TMEM99, TMEM9B, TTC39B, TULP3, UGCG, V-ATPase D, VAP-B/C, VPS35, VPS8, WBSCR17, WDR17, and ZFYVE26.Activator of:
γ2-Adaptin, 9330182L06Rik, Alphavirus, ATP10A, BLOS3, C17orf49_0610010K14Rik, C17orf59, CHMP4, CHMP5, Clathrin HC, CYP46, D030016E14Rik, D030074E01Rik, DC-LAMP, DHCR24, ENSMUSG00000056133, FAN, Flavivirus, Flotillin-1, Flotillin-2, HPS-3, INSIG-2, LAPTM4B, LIMP III, LOC284274, LOC339674, Lyst, Maspardin, MENTHO, MFSD8, MLN64, MVB12B, NEEP21, NEURL4, O-Ac GD3, OS4, OSBP, OSBP2, PIG-K, PIS1, PLEKHF2, PLEKHM1, Rab 18, Rab11-FIP5, Rabaptin-5β, Shigatoxin 1, SNX1, SNX22, SNX25, SNX31, Syntaxin 17, TMED1, TMEM183A, TMEM199, TMEM45B, TMEM9, V-ATPase C1, VPS13A, VPS13C, VPS16, VPS28, VPS29, VPS37, VPS37A, VPS41, VPS4B, Vrho, and WDR36.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U 18666A, 10 mg | sc-203306 | 10 mg | $143.00 | |||
U 18666A, 50 mg | sc-203306A | 50 mg | $510.00 |