Molecular structure of Vismodegib, CAS Number: 879085-55-9
Vismodegib (CAS 879085-55-9)
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Alternate Names:
HhAntag691; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
Application:
Vismodegib is a potent hedgehog (Hh) signaling pathway inhibitor
CAS Number:
879085-55-9
Purity:
≥99%
Molecular Weight:
421.30
Molecular Formula:
C19H14Cl2N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vismodegib is a potent hedgehog (Hh) signaling pathway inhibitor. Vismodegib is a potent inhibitor of two ABC transporters, ABCG2 and Mdr-1 (ABCB1), with IC50 values of 1.4 and 3.0 muM, respectively. Vismodegib may have antitumor activity in locally advanced or metastatic basal-cell carcinoma. In vitro studies are conducted to examine the mechanism of action, biological activity, biochemical and physiological effects of vismodegib. These studies have demonstrated that vismodegib is a powerful inhibitor of the hedgehog pathway and possesses the ability to hinder the proliferation of cancer cells in a dosage-dependent manner. Furthermore, vismodegib has been observed to reduce the expression of various genes involved in cell growth and differentiation, including the genes responsible for encoding Smoothened, Gli1, and Gli2 proteins.
Vismodegib (CAS 879085-55-9) References
- Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers. | De Smaele, E., et al. 2010. Curr Opin Investig Drugs. 11: 707-18. PMID: 20496266
- Vismodegib for the treatment of basal cell skin cancer. | Poggi, L. and Kolesar, JM. 2013. Am J Health Syst Pharm. 70: 1033-8. PMID: 23719880
- Mechanisms and efficacy of vismodegib in the treatment of basal cell carcinoma. | Amin, SH., et al. 2013. Discov Med. 16: 229-32. PMID: 24229739
- Vismodegib: an inhibitor of the Hedgehog signaling pathway in the treatment of basal cell carcinoma. | Proctor, AE., et al. 2014. Ann Pharmacother. 48: 99-106. PMID: 24259609
- Vismodegib: a review. | Ruiz-Salas, V., et al. 2014. Actas Dermosifiliogr. 105: 744-51. PMID: 24359667
- Vismodegib: A Review in Advanced Basal Cell Carcinoma. | Frampton, JE. and Basset-Séguin, N. 2018. Drugs. 78: 1145-1156. PMID: 30030732
- Vismodegib. | Meiss, F., et al. 2018. Recent Results Cancer Res. 211: 125-139. PMID: 30069764
- Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion. | Dummer, R., et al. 2020. J Eur Acad Dermatol Venereol. 34: 1944-1956. PMID: 31990414
- Neoadjuvant vismodegib in the management of locally advanced periocular basal cell carcinoma. | Curragh, DS., et al. 2021. Eye (Lond). 35: 2740-2745. PMID: 33235336
- Vismodegib and radiotherapy combination in treatment of cancer. | Benderli Cihan, Y. 2021. J BUON. 26: 2203-2204. PMID: 34761638
- Inhibition of smoothened receptor by vismodegib leads to micrognathia during embryogenesis. | Guo, Y., et al. 2022. Differentiation. 125: 27-34. PMID: 35429807
- Vismodegib and Sonidegib in Locally Advanced and Metastatic Basal Cell Carcinoma: Update on Hedgehog Pathway Inhibitors. | Kurnia Wijaya, J., et al. 2022. Actas Dermosifiliogr. 113: 443-450. PMID: 35697404
- Vismodegib, a sonic hedgehog signalling blockade, ameliorates ovalbumin and ovalbumin/lipopolysaccharide-induced airway inflammation and asthma phenotypical models. | El-Baz, LMF., et al. 2022. Life Sci. 310: 121119. PMID: 36306870
Inhibitor of:
1810043G02Rik, 4930546H06Rik, ABCG2, APCDD1L, ARF7, ASCL1, B9D1, BBS5, BOC, BRINP3_Fam5c, C1orf112, C20orf26, C2CD3, C6orf182_2410017P07Rik, CCDC152, CELSR1, DAND5, DAZ Interacting Zinc Finger Proteins (DZIP), DCHS2, DISP1, DISP2, Dlx-2, DSCR 8, E330017A01Rik, EG216818, EG435927, ephrin-A5, FAM124A, FEZF1, FJX1, Fmi2, FOXC2, FOXD3, Gas1, GBX2, GLI-1, GLI-2, GLIPR1L3, GUP1, HATH-1, HDRP, hedgehog, HH, HHAT, Hhip, HHIPL1, HHIPL2, HoxA1, HoxB2, HoxB5, HoxD13, HoxD8, IFT140, IFT80, Ihh, INTU, IRX5, KCTD7, KHDC1L, KIAA0562, KIAA0586, KIAA1822L, LELP1, LHX1, LHX3, LMBR1, LMBR1L, LOC100041061, LOC100041436, LOC257407, LOC388237, LOC388963, LOC645655, LOC729556, LRRC6, LRRN3, MAB21L2, MACS1, MAMLD1, MATH-1, MATH-3, Mdr-1, MESP2, OFD1, Olr496, otoancorin, patched, patched 2, PCDHB1, PCDHB2, Pitx2, PTCHD1, PTCHD2, PTCHD3, PTCHD4, RFX4, ROPN1, SCUBE1, SDCCAG8, SEBOX, SFMBT1, Slit3, Smo, SMOC-1, smoothened, Sox19, STK36, Su(fu), TAFA3, TBX6, Tect1, TMEM218, TMEM231, TRBV1, TTC21B, TULP3, V1RG12, VAX1, WDR11, Zic1, Zic5, and ZNF318.Activator of:
atonal, Cdx1, DISP2, EVC2, GLI-2, GLI-4, Hhip, IFT172, MIA2, Olfr394, PRDM13, Shh, Smad7, Suppressor of Hairless, and UHRF1BP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vismodegib, 10 mg | sc-396759 | 10 mg | $82.00 | |||
Vismodegib, 25 mg | sc-396759A | 25 mg | $158.00 |