T1-cadherin Inhibitors
T1-cadherin inhibitors encompass a range of chemicals that target the adhesive functions of T1-cadherin directly or indirectly through associated pathways. Central to cadherins, including T1-cadherin, is their reliance on calcium for adhesive interactions. EGTA, a calcium chelator, directly impedes this calcium-dependent adhesive function by sequestering calcium ions. This disruption impacts the integrity of cadherin-mediated cell-cell junctions.
Alongside this direct approach, various compounds target pathways intertwined with cadherin-mediated signaling. The PI3K pathway is known to be an intersection for multiple cellular processes, including those mediated by cadherins. Compounds like LY294002 and Wortmannin inhibit the PI3K pathway, indirectly influencing T1-cadherin's functions. In the complex web of cellular signaling, T1-cadherin is also impacted by the Wnt/beta-catenin and TGF-beta pathways. Chemicals like XAV939, IWP-2, and SB431542 interfere with these pathways, thus wielding an indirect influence over T1-cadherin's role in cell adhesion and communication. Furthermore, the Notch signaling pathway, when modulated by DAPT, demonstrates the intricate network of pathways that have the capacity to impact T1-cadherin function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
A calcium chelator. Cadherins are calcium-dependent for their adhesive functions, thus EGTA can disrupt their adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor. This pathway may interact with cadherin-mediated pathways. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits non-muscle myosin II. Myosin is involved in cell-cell adhesion processes which can affect cadherin function. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
A neutral sphingomyelinase inhibitor. Affects sphingolipid metabolism, potentially influencing membrane dynamics and cadherin functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor, affecting cadherin-mediated pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor. MEK pathways might be related to cadherin signaling, thereby indirectly influencing cadherin function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-beta receptor inhibitor. TGF-beta signaling can influence cadherin-mediated pathways. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Tankyrase inhibitor affecting Wnt/beta-catenin signaling, which plays roles in cellular adhesion and cadherin function. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Wnt production inhibitor. By targeting Wnt signaling, it can affect cadherin function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
A gamma-secretase inhibitor which can influence Notch signaling, potentially affecting cadherin-associated pathways. | ||||||