EGTA CAS: 67-42-5
MF: C14H24N2O10
MW: 380.35

EGTA (CAS 67-42-5)

EGTA | CAS 67-42-5 is rated 5.0 out of 5 by 1.
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Alternate Names: EGTA is also known as Ethylene Glycol Tetraacetic Acid.
Application: EGTA is a chelator with specificity for calcium ions used to determine calcium in the presence of magnesium.
CAS Number: 67-42-5
Purity: ≥97%
Molecular Weight: 380.35
Molecular Formula: C14H24N2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

EGTA is a useful chemical in a variety of buffers, EGTA is a chelating agent useful for the determination of calcium in the presence of magnesium, since EGTA has greater specificity for calcium ions. Inhibitor of alkaline phosphatase activity which is useful in ELISA reactions. EGTA is shown to activate Ca2+-stimulated ATPase in rat liver plasma membranes and induce apoptosis in PC12 cells. EGTA also inhibits the zinc-dependent endopeptidases, Matrix metalloproteinases (MMPs).


References

1. Brauner, P. and Fridlender, B. 1981. J. Immunol. Methods. 42: 375-379. PMID: 6270211

2. Birch-Machin, M.A., et al.1986. Biochim. Biophys. Acta. 855: 277-285. PMID: 2936394

3. Riley, W.W. and Pfeiffer, D.R. 1986. J. Biol. Chem. 261: 28-31. PMID: 2416747

4. Vidal, H., et al. 1991. Anal. Biochem. 193: 135-141. PMID: 1645932

5. Lindenboim, L., et al. 1995. J. Neurochem. 64: 1054-1063. PMID: 7861134

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 1M NaOH (100 mM), Slightly soluble in water.
Storage :
Store at room temperature
Melting Point :
241° C
Boiling Point :
~678.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
HIV-1(RF): EC5050 = > 94.7 µM (CEM-SS); HIV-1(RF): EC5050 = > 328.65 µM (CEM-SS)
pK Values :
pKa: 1.47, pKb: 9.29
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AH3760000
PubChem CID :
Merck Index :
14: 3529
MDL Number :
MFCD00004291
EC Number :
200-651-2
Beilstein Registry :
1717370
SMILES :
C(COCCOCCN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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EGTA (CAS 67-42-5)  Product Citations

See how others have used EGTA (CAS 67-42-5). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 30797785  Quan, H.|Bae, HB.|Hur, YH.|Lee, KH.|Lee, CH.|Jang, EA.|Jeong, S.| et al. 2019. Eur. J. Pharmacol. 852: 125-133.

PMID: # 29552635  Sawicki, LA.|Choe, LH.|Wiley, KL.|Lee, KH.|Kloxin, AM.| et al. 2018. ACS Biomater Sci Eng. 4: 836-845.

PMID: # 29035389  Benthani, FA. et al. 2018. Oncogene. 37: 663-672.

PMID: # 30224682  Soliman, M.|Cho, EH.|Park, JG.|Kim, JY.|Alfajaro, MM.|Baek, YB.|Kim, DS.|Kang, MI.|Park, SI.|Cho, KO.| et al. 2018. Sci Rep. 8: 13931.

PMID: # 30369865  Duncan, DS.|Weiner, RL.|Weitlauf, C.|Risner, ML.|Roux, AL.|Sanford, ER.|Formichella, CR.|Sappington, RM.| et al. 2018. Front Neurosci. 12: 702.

PMID: # 24962405  Ahn, JH. et al. 2014. J. Vet. Sci. 15: 335-42.

PMID: # 24962405  Ahn, JH. et al. 2014. J. Vet. Sci. 15: 335-42.

PMID: # 17136494  Nakano, K.|Saito, K.|Mine, S.|Matsushita, S.|Tanaka, Y.| et al. 2007. Apoptosis. 12: 45-54.

PMID: # 11784871  Ueki, K. et al. 2002. Mol. Cell. Biol. 22: 965-977.

PMID: # 11489966  Gewirtz, A.T. et al. 2001. J. Immunology. 167: 1882-1885.

Citations 1 to 10 of 20 total
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Rated 5 out of 5 by from By WB By WB, it was observed that EGTA inhibits lambda protein phosphatase, thus a strong signal is maintained for phosphorylated Cofilin 1. -SCBT QC
Date published: 2015-03-02
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