IWP-2 CAS: 686770-61-6
MF: C22H18N4O2S3
MW: 466.60
An inhibitor of Wnt production.

IWP-2 (CAS 686770-61-6)

IWP-2 | CAS 686770-61-6 is rated 5.0 out of 5 by 1.
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Synonym: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Application: An inhibitor of Wnt production
CAS Number: 686770-61-6
Purity: ≥98%
Molecular Weight: 466.60
Molecular Formula: C22H18N4O2S3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks β-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.


References

1. Chen, Baozhi., et al., 2009. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology. 5(2): 100-7. PMID: 19125156

Appearance :
powder
Physical State :
Solid
Solubility :
Soluble in DMSO: 5 mg/mL
Storage :
Desiccate at room temperature
Melting Point :
316.82° C (Predicted)
Boiling Point :
723.12° C (Predicted)
Density :
1.5 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2155128
SMILES :
CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

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Certificate of Analysis

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IWP-2  Product Citations

See how others have used IWP-2. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 17 total

PMID: # 30886000  Ahuja, G.|Bartsch, D.|Yao, W.|Geissen, S.|Frank, S.|Aguirre, A.|Russ, N.|Messling, JE.|Dodzian, J.|Lagerborg, KA.|Vargas, NE.|Muck, JS.|Brodesser, S.|Baldus, S.|Sachinidis, A.|Hescheler, J.|Dieterich, C.|Trifunovic, A.|Papantonis, A.|Petrascheck, M.|Klinke, A.|Jain, M.|Valenzano, DR.|Kurian, L.| et al. 2019. EMBO Rep. 20:

PMID: # 30679991  Sun, S.|Gong, C.|Yuan, K.| et al. 2019. Exp Ther Med. 17: 1182-1189.

PMID: # 31285284  Zambrano, S.|Möller-Hackbarth, K.|Li, X.|Rodriguez, PQ.|Charrin, E.|Schwarz, A.|Nyström, J.|Wernerson, AÖ.|Lal, M.|Patrakka, J.| et al. 2019. J. Am. Soc. Nephrol.

PMID: # 30070325  2018. Eur Rev Med Pharmacol Sci. 22: 4898-4907.

PMID: # 29511261  Saez, I.|Koyuncu, S.|Gutierrez-Garcia, R.|Dieterich, C.|Vilchez, D.| et al. 2018. Sci Rep. 8: 4092.

PMID: # 29510587  Takahashi, T.|Shiraishi, A.|Murata, J.| et al. 2018. Int J Mol Sci. 19:

PMID: # 29129916  Ju Lee, H.|Bartsch, D.|Xiao, C.|Guerrero, S.|Ahuja, G.|Schindler, C.|Moresco, JJ.|Yates, JR.|Gebauer, F.|Bazzi, H.|Dieterich, C.|Kurian, L.|Vilchez, D.| et al. 2017. Nat Commun. 8: 1456.

PMID: # 28811218  Hübner, K. et al. 2017. Dev. Biol. 430: 142-155.

PMID: # 27892468  Noormohammadi, A. et al. 2016. Nat Commun. 7: 13649.

PMID: # 26803770  Malan, D. et al. 2016. Basic Res. Cardiol. 111: 14.

Citations 1 to 10 of 17 total

What is the solubility of this product in DMSO?

Asked by: hawkeye11
IWP-2 (CAS 686770-61-6) is soluble in DMSO at a concentration of 29 mg/mL.
Answered by: Tech Service 11
Date published: 2018-10-14

What temperature should solutions in DMSO be stored?

Asked by: Io5ay
Thank you for your question. IWP-2, sc-252928, should be stored at room temperature when dissolved in DMSO.
Answered by: TechService7
Date published: 2016-12-16
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Rated 5 out of 5 by from Worked well in our experiments Worked well in our experiments.
Date published: 2015-06-10
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