Molecular structure of IWP-2, CAS Number: 686770-61-6
IWP-2 (CAS 686770-61-6)
See product citations (27)
Alternate Names:
IWP-2 is also known as inhibitor of Wnt Production-2.
Application:
IWP-2 is an inhibitor of Wnt production, able to inactivate Porcn function by modulation of Porcn regulated active sites.
CAS Number:
686770-61-6
Purity:
≥98%
Molecular Weight:
466.60
Molecular Formula:
C22H18N4O2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IWP-2 is an inactivator of Porcn function, and inhibitor of Wnt production. The Wnt/b-catenin (′canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to the disease stage. IWP-2 inhibits Wnt production. It appears that IWP-2 inactivates Porcn function either by modulating the function of a Porcn regulator or by directly inhibiting the Porcn active site. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 has been used to suppress embryonic stem cell self-renewal.
IWP-2 (CAS 686770-61-6) References
- The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. | Maiti, G., et al. 2012. Proc Natl Acad Sci U S A. 109: 16600-5. PMID: 23012420
- Wasf2: a novel target of intermittent parathyroid hormone administration. | Uyama, M., et al. 2013. Int J Mol Med. 31: 1243-7. PMID: 23525371
- Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. | Mo, ML., et al. 2013. Oncol Lett. 5: 1719-1723. PMID: 23761839
- Regulation of chondrosarcoma invasion by MMP26. | Xu, X., et al. 2015. Tumour Biol. 36: 365-9. PMID: 25262277
- Regulation of autophagy of prostate cancer cells by β-catenin signaling. | Lin, R., et al. 2015. Cell Physiol Biochem. 35: 926-32. PMID: 25633614
- Wnt/Glycogen Synthase Kinase 3β/β-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection. | Liu, JD., et al. 2015. Chin Med J (Engl). 128: 2346-53. PMID: 26315083
- Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. | García-Reyes, B., et al. 2018. J Med Chem. 61: 4087-4102. PMID: 29630366
- Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain. | Zhao, Y. and Yang, Z. 2018. Exp Ther Med. 16: 3082-3088. PMID: 30214530
- Hsa-miR-942 fingerprint in colorectal cancer through Wnt signaling pathway. | Fasihi, A., et al. 2019. Gene. 712: 143958. PMID: 31278963
- Myometrial Cells Stimulate Self-Renewal of Endometrial Mesenchymal Stem-Like Cells Through WNT5A/β-Catenin Signaling. | Cao, M., et al. 2019. Stem Cells. 37: 1455-1466. PMID: 31414525
- LGR5 induces β-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma. | Kawasaki, K., et al. 2021. Liver Int. 41: 865-881. PMID: 33249719
- Aggressiveness of 4T1 breast cancer cells hampered by Wnt production-2 inhibitor nanoparticles: An in vitro study. | Ben Ghedalia-Peled, N., et al. 2021. Int J Pharm. 596: 120208. PMID: 33493601
- Wnt/β-catenin signaling pathway is involved in early dopaminergic differentiation of trabecular meshwork-derived mesenchymal stem cells. | Sahebdel, F., et al. 2022. J Cell Biochem. 123: 1120-1129. PMID: 35533251
- Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells. | Kornsuthisopon, C., et al. 2022. Sci Rep. 12: 7583. PMID: 35534526
- Cell osteogenic bioactivity mediated precisely by varying scaled micro-pits on ordered micro/nano hierarchical structures of titanium. | Zhang, Y., et al. 2022. Regen Biomater. 9: rbac046. PMID: 35855110
Inhibitor of:
β-sarcoglycan, 1700061G19Rik, 2310002L09Rik, 2410012M07Rik, 3110007F17Rik, 4930511I11Rik, 6330545A04Rik, 9430069J07Rik, ANKRD33B, AP-2ε, APCDD1, ARMC5, ARMC7, Axin, Barx2, BC1D14, BCA3, Bcl-9, beta-catenin, betaKlotho, Bex2, BICC1, BMP-8B, BR-cadherin, brachyury 2, BTBD7, C14orf39, C15orf59, C16orf78, C16orf88, C17orf77, C18orf19, C1orf122, C1orf172_1810019J16Rik, C1orf65, C20orf149, C20orf194, C20orf195, C20orf3, C22orf36_AI646023, C9orf16, cadherin-24, cadherin-26, Calcipressin-2, CBWD5, CCDC121, CCDC144NL, CCDC48, CDH20, CELSR2, CELSR3, CHADL, Claudin (CLDN), claudin-12, claudin-6, CMTM3, CREG2, CTNNAL1, DAAM1, DAPLE, Dapper3, DCHS1, Dmp1, DPPA2, DQX1, DRG11, E330017A01Rik, EG245190, EG435927, Enzyme, ephrin-A3, Esgp, F-Spondin, FAM123A, FAM124A, FEZF1, FJX1, FLJ39639, FLJ45513, Fmi2, FOXD3, FOXD4, FOXF1, FREM2, frizzled-8, GATA-6, GHS-R1, GLIPR1L3, Gm12, Gm765, GPR177, GPRC5B, HE4, HESX1, HIP1, HIP12, HIP3, HOS, HOXA3, HoxD8, IQCK, IRX5, ITF-1, K12, KIAA1731, Kremen-2, KRTAP16-9, LACTBL1, LBX2, LEF-1, LGR5, LGR6, LHFPL4, Limd2, LIN-44, Lingo-4, LMBR1L, LMO6, LOC100041222, LOC100041430, LOC100042018, LOC257407, LOC388963, LOC635396, LOC642892, LOC644361, LOC651033, LOC728222, LRP12, LRP5, LRP6, LRRC27, LRRC28, LRTM1, Lunatic Fringe, Ly-6A/E, LYPD4, LZTFL1, MAB-5, MATH-2, MDFIC, MESDC2, MESP1, MKX, myotublarin, NK homeobox (NKX), Nkx-2.2, Nkx-3.2, Nkx-6.3, Nlk, Notum, nov, Obox2, Odf4, Olfr48, Olfr480, Olfr483, Olfr484, Olfr843, Olfr876, Olfr877, Olfr878, OLIG2, Olr490, Otolin-1, PARD3B, PCDH11X, PCDH8, PCDH9_Pcdh9, PCDHA11, PCDHAC, PCDHB1, Pcdhb19, PCDHB2, PCDHGB1, Pfpl, PICOT, Pitx2, POD-1, PORCN, Prickle4, R-Spondin, R-Spondin3, R-Spondin4, Ran BP-10, RBFOX3/NeuN, Ripply2, RWDD3, Scratch1, SEBOX, SEMA3C, sGC α2, sGC β1, SH3GL1, Sipa1l3, Six2, Smuc, Sox-7, SPANX-N, Spondin (SPON), T1-cadherin, TBX10, TBX5, TCP-10a, TCP10L, Teneurin-2, Teneurin-3, THSD7B, TMEM147, TMEM170B, TMEM26, TMEM46, TMEM88, TMEM8C, TMEM9, Trimethyl Arg Asymmetric, TSHZ1, TTC30B, UNC5H2, UNCX, UNQ6126, utrophin, V1RC18, V1RG12, Veli2, Veli3, VENTX2, WAPL, WDPCP, WDR59, WFIKKN, WISP-3, Wnt, WNT (Wingless Int-1), Wnt-1, Wnt-10b, Wnt-14b, Wnt-2, Wnt-3a, Wnt-5b, Wnt-6, Wnt-7a, WTIP, YAF2, ZNF236, ZNF66, ZNF681, ZNF699, ZSWIM2, and ZUD_UNC5CL.Activator of:
ADAM15, AIDA, ALX1, Ankyrin B, BAR-1, BC053393, CELSR1, CKAP4, Codanin-1, Crumbs, dishevelled, DIXDC1, Dvl-3, E-cadherin, E230019M04Rik, EG245190, eHAND, Evx-1, EXDL3, EXOSC4, Flamingo, FNDC3B, FOXC1, FOXP4, frizzled-1, FRP-4, HoxA1, HoxC4, HPV16 E4, Id4, INTU, Kremen-1, Kremen-2, Lefty-1, Lefty-A, Lefty-B, LGR4, LIN-44, LMX1A, LTBP-4, MAGI-3, Manic Fringe, MINK1, NIPSNAP3A, PCDHA9, Prickle1, RASAL2, RNF43, RPESP, RYK, SCAI, Sox-17, SUSD2, TCF-1, Testican-1, TIFAB, TMEM170B, TMEM59, TMPRSS4, Vangl1, WIF-1, Wingless, Wnt-10b, and Wnt-8b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IWP-2, 5 mg | sc-252928 | 5 mg | $96.00 | |||
IWP-2, 25 mg | sc-252928A | 25 mg | $292.00 |