T1-cadherin Activators
T1-cadherin Activators encompasses a diverse group of compounds that share the ability to enhance the expression or activity of the T1-cadherin protein. These activators can be broadly categorized into two main groups: direct activators and indirect activators.
Direct activators of T1-cadherin directly interact with the protein and enhance its function. One example is SDS, a detergent that disrupts cell membranes and exposes the extracellular domain of T1-cadherin to its ligands. Similarly, CPC, Triton X-100, octyl glucoside, and digitonin are all detergents that can activate T1-cadherin by disrupting cell membranes. Additionally, reducing agents such as βME and DTT can activate T1-cadherin by breaking disulfide bonds in the protein, which can expose cryptic epitopes on the protein that can be recognized by antibodies or other ligands. Indirect activators of T1-cadherin, on the other hand, do not directly interact with the protein but instead modulate its expression or activity through upstream signaling pathways. For instance, LiCl, forskolin, staurosporine, wortmannin, rapamycin, and U0126 are all inhibitors of kinases that negatively regulate T1-cadherin expression. By inhibiting these kinases, these compounds can indirectly activate T1-cadherin expression.The activation of T1-cadherin has a variety of effects on cells, including promoting cell adhesion, migration, and differentiation. T1-cadherin is also involved in a variety of cellular processes, including cell signaling, cell growth, and apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium dodecyl sulfate | 151-21-3 | sc-264510 sc-264510A sc-264510B sc-264510C | 25 g 100 g 500 g 1 kg | $78.00 $119.00 $419.00 $603.00 | 11 | |
Sodium dodecyl sulfate (SDS) is an anionic detergent that can activate T1-cadherin by disrupting cell membranes and exposing the extracellular domain of T1-cadherin to its ligands. SDS is a commonly used laboratory detergent that is used to solubilize proteins and disrupt cell membranes. | ||||||
Triton X-100 | 9002-93-1 | sc-29112 sc-29112A | 100 ml 500 ml | $20.00 $42.00 | 55 | |
Triton X-100 is a nonionic detergent that can activate T1-cadherin by disrupting cell membranes and exposing the extracellular domain of T1-cadherin to its ligands. Triton X-100 is a commonly used laboratory detergent that is used to solubilize proteins and disrupt cell membranes. | ||||||
Digitonin | 11024-24-1 | sc-280675A sc-280675 sc-280675B sc-280675C sc-280675D sc-280675E | 100 mg 250 mg 1 g 2.5 g 5 g 10 g | $84.00 $180.00 $385.00 $935.00 $1679.00 $2929.00 | 10 | |
Digitonin is a saponin that can activate T1-cadherin by solubilizing cell membranes and exposing the extracellular domain of T1-cadherin to its ligands. Digitonin is a natural detergent that is often used to solubilize membrane proteins without denaturing them. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
β-mercaptoethanol (βME) is a reducing agent that can activate T1-cadherin by breaking disulfide bonds in the protein. This can expose cryptic epitopes on the protein that can be recognized by antibodies or other ligands. βME is a commonly used reducing agent in biochemistry. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-ethylmaleimide (NEM) is an alkylating agent that can activate T1-cadherin by modifying cysteine residues in the protein. This can alter the protein's structure and function. NEM is a commonly used alkylating agent in biochemistry. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
Iodoacetamide (IAM) is an alkylating agent that can activate T1-cadherin by modifying cysteine residues in the protein. This can alter the protein's structure and function. IAM is a commonly used alkylating agent in biochemistry. | ||||||