SUV39H1 Activators
SUV39H1 activators belong to a specialized class of chemical compounds designed to modulate the activity of the SUV39H1 enzyme, which is a histone methyltransferase. Histone methyltransferases play a pivotal role in the epigenetic regulation of gene expression by modifying histone proteins, the structural components of chromatin that package and organize DNA in the cell nucleus. SUV39H1, specifically, is known for its role in adding methyl groups to histone H3 at lysine 9 (H3K9), a modification associated with gene silencing and heterochromatin formation. This process is critical for the maintenance of genome stability, gene regulation, and cellular differentiation. By modulating the activity of SUV39H1, researchers can investigate its influence on chromatin structure and gene expression patterns.
SUV39H1 activators are designed to interact with the SUV39H1 enzyme, modulating its methyltransferase activity and impacting the epigenetic marks on histone proteins. These compounds serve as essential tools for scientists studying the epigenetic regulation of gene expression and chromatin dynamics. By manipulating SUV39H1 activity, researchers aim to gain insights into the molecular mechanisms governing gene silencing and the establishment of heterochromatin. SUV39H1 activators play a crucial role in advancing our understanding of the epigenetic modifications that shape the functional genome, contributing to the broader field of molecular biology and providing valuable insights into the regulation of gene expression and genome organization.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
Ademetionine is a methyl donor in various biological methylation reactions, including histone methylation. It is essential for SUV39H1's methyltransferase activity. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat, a global histone methylation inhibitor, can paradoxically increase SUV39H1 activity by disrupting negative feedback loops in histone methylation regulation. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin, a specific inhibitor of SUV39H1, can induce compensatory mechanisms in cells that lead to the upregulation and activation of SUV39H1 under certain conditions. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294, primarily a G9a and GLP inhibitor, can influence the balance of histone methylation, indirectly affecting SUV39H1 activity through compensatory cellular mechanisms. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
As an inhibitor of SIRT1, a class III histone deacetylase, nicotinamide can indirectly influence SUV39H1 activity by altering chromatin structure and accessibility. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Known to inhibit histone acetyltransferases (HATs), anacardic acid can alter chromatin dynamics in a way that might favor SUV39H1 mediated methylation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132, a proteasome inhibitor, can stabilize proteins involved in histone modification, potentially increasing SUV39H1 activity indirectly by affecting its regulatory proteins. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As a HDAC inhibitor, Suberoylanilide Hydroxamic Acid changes the chromatin state, which can indirectly upregulate SUV39H1 activity by altering the transcription of genes involved in histone methylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, another HDAC inhibitor, can indirectly impact SUV39H1 activity by modifying chromatin structure and influencing the expression of genes involved in histone methylation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Originally an alcohol deterrent, disulfiram has been shown to affect various cellular pathways, including those that might indirectly increase SUV39H1 activity. | ||||||